Topical tretinoin (retinoic acid) improves early stretch marks

Sewon Kang, Kwang J. Kim, Christopher E.M. Griffiths, Tai Yuen Wong, Harvinder S. Talwar, Gary J. Fisher, David Gordon, Ted A. Hamilton, Charles N. Ellis, John J. Voorhees

Research output: Research - peer-reviewArticle

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Abstract

Background and Design: Stretch marks are disfiguring lesions usually caused by excessive stretching of skin. We investigated the response of early, clinically active stretch marks to topical 0.1% tretinoin (retinoic acid) cream. In a double-blind, randomized, vehicle-controlled study, 22 patients applied either 0.1% tretinoin (n=10) or vehicle (n=12) daily for 6 months to the affected areas. Patients were evaluated by physical examination monthly and by analysis of biopsy specimens of stretch marks obtained before and at the end of therapy in comparison with untreated normal skin. Results: After 2 months, patients treated with tretinoin had significant improvement in severity scores of stretch marks compared with patients who received vehicle (P<.05). After 6 months, eight (80%) of the 10 tretinoin-treated patients had definite or marked improvement compared with one (8%) of the 12 vehicle-treated patients (P=.002). Targeted stretch marks in patients treated with tretinoin had a decrease in mean length and width of 14% and 8%, respectively, compared with an increase of 10% (P<.001) and 24% (P=.008), respectively, in patients who received vehicle. There were no significant differences in various measures of quality and quantity of dermal collagen and elastic fibers in stretch marks when tretinoin and vehicle treatments were compared. Conclusions: Topical application of tretinoin significantly improves the clinical appearance of early, active stretch marks. The processes that are responsible for the clinical improvement remain unknown.

LanguageEnglish (US)
Pages519-526
Number of pages8
JournalArchives of Dermatology
Volume132
Issue number5
DOIs
StatePublished - May 1 1996

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Striae Distensae
Tretinoin
Skin
Therapeutics
Elastic Tissue
Physical Examination
Collagen
Biopsy

ASJC Scopus subject areas

  • Dermatology

Cite this

Kang, S., Kim, K. J., Griffiths, C. E. M., Wong, T. Y., Talwar, H. S., Fisher, G. J., ... Voorhees, J. J. (1996). Topical tretinoin (retinoic acid) improves early stretch marks. Archives of Dermatology, 132(5), 519-526. DOI: 10.1001/archderm.132.5.519

Topical tretinoin (retinoic acid) improves early stretch marks. / Kang, Sewon; Kim, Kwang J.; Griffiths, Christopher E.M.; Wong, Tai Yuen; Talwar, Harvinder S.; Fisher, Gary J.; Gordon, David; Hamilton, Ted A.; Ellis, Charles N.; Voorhees, John J.

In: Archives of Dermatology, Vol. 132, No. 5, 01.05.1996, p. 519-526.

Research output: Research - peer-reviewArticle

Kang, S, Kim, KJ, Griffiths, CEM, Wong, TY, Talwar, HS, Fisher, GJ, Gordon, D, Hamilton, TA, Ellis, CN & Voorhees, JJ 1996, 'Topical tretinoin (retinoic acid) improves early stretch marks' Archives of Dermatology, vol 132, no. 5, pp. 519-526. DOI: 10.1001/archderm.132.5.519
Kang S, Kim KJ, Griffiths CEM, Wong TY, Talwar HS, Fisher GJ et al. Topical tretinoin (retinoic acid) improves early stretch marks. Archives of Dermatology. 1996 May 1;132(5):519-526. Available from, DOI: 10.1001/archderm.132.5.519
Kang, Sewon ; Kim, Kwang J. ; Griffiths, Christopher E.M. ; Wong, Tai Yuen ; Talwar, Harvinder S. ; Fisher, Gary J. ; Gordon, David ; Hamilton, Ted A. ; Ellis, Charles N. ; Voorhees, John J./ Topical tretinoin (retinoic acid) improves early stretch marks. In: Archives of Dermatology. 1996 ; Vol. 132, No. 5. pp. 519-526
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