Socially-induced brain 'fertilization': Play promotes brain derived neurotrophic factor transcription in the amygdala and dorsolateral frontal cortex in juvenile rats

Nakia S. Gordon, Sharon Burke, Huda Akil, Stanley J. Watson, Jaak Panksepp

Research output: Contribution to journalArticle

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Abstract

Rough and tumble (R&T) play is assumed to have beneficial effects in developing organisms. To evaluate this idea, brain derived neurotrophic factor (BDNF) gene expression was evaluated in 32-day-old juvenile rats that were allowed to play for 30 min prior to sacrifice. In situ hybridization for BDNF mRNA revealed that the amygdala and dorsolateral frontal cortex had significantly elevated BDNF mRNA expression as a result of play. These effects suggest that play may help program higher brain regions involved in emotional behaviors.

LanguageEnglish (US)
Pages17-20
Number of pages4
JournalNeuroscience Letters
Volume341
Issue number1
DOIs
StatePublished - Apr 24 2003

Fingerprint

Brain-Derived Neurotrophic Factor
Frontal Lobe
Amygdala
Fertilization
Brain
Messenger RNA
In Situ Hybridization
Gene Expression

Keywords

  • Amygdala
  • Dorsolateral frontal cortex
  • Neurodevelopment
  • Neuronal circuitry
  • Rough and tumble play

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Socially-induced brain 'fertilization' : Play promotes brain derived neurotrophic factor transcription in the amygdala and dorsolateral frontal cortex in juvenile rats. / Gordon, Nakia S.; Burke, Sharon; Akil, Huda; Watson, Stanley J.; Panksepp, Jaak.

In: Neuroscience Letters, Vol. 341, No. 1, 24.04.2003, p. 17-20.

Research output: Contribution to journalArticle

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