Bone Regeneration

Suzanne Stewart, Stephanie J. Bryant, Jaimo Ahn, Kurt D. Hankenson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Bone is a mineralized connective tissue that provides the structural support for the body and serves an important role in systemic physiology, including mineral metabolism. Bone is unique in that under sufficient physiological conditions with appropriate mechanical stabilization, it has robust regenerative capacity and heals in a scarless manner. Regenerative methodologies that have been developed to enhance healing include primarily surgical approaches, including methods to increase mechanical stability, debridement at the fracture site, and the delivery of graft material to enhance healing. Despite the robust healing capacity and the currently available healing adjuncts, 5-10% of fractures show either delay in healing or complete failure to adequately heal. Therefore, there is a significant need to develop methodologies to improve bone healing. In order to develop new regenerative therapies, clinicians and scientists must develop an enhanced understanding of normal fracture physiology and the specific pathology associated with abnormal fracture healing. Novel treatment regimens in the future will likely be individualized and based on a nuanced understanding of the temporal and spatial requirements of mechanical load, cells, growth factors, and vascularization in order to deliver the ideal bioengineered therapeutic.

LanguageEnglish (US)
Title of host publicationTranslational Regenerative Medicine
PublisherElsevier Inc.
Pages313-333
Number of pages21
ISBN (Electronic)9780124104570
ISBN (Print)9780124103962
DOIs
StatePublished - Dec 2 2014
Externally publishedYes

Fingerprint

Bone Regeneration
Bone and Bones
Fracture Healing
Debridement
Connective Tissue
Minerals
Intercellular Signaling Peptides and Proteins
Pathology
Transplants
Therapeutics

Keywords

  • Biomaterial
  • Bone
  • Bone regeneration
  • Chondrocyte
  • Fracture healing
  • Growth factor
  • Mineral
  • Osteoblast

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Stewart, S., Bryant, S. J., Ahn, J., & Hankenson, K. D. (2014). Bone Regeneration. In Translational Regenerative Medicine (pp. 313-333). Elsevier Inc.. DOI: 10.1016/B978-0-12-410396-2.00024-4

Bone Regeneration. / Stewart, Suzanne; Bryant, Stephanie J.; Ahn, Jaimo; Hankenson, Kurt D.

Translational Regenerative Medicine. Elsevier Inc., 2014. p. 313-333.

Research output: Chapter in Book/Report/Conference proceedingChapter

Stewart, S, Bryant, SJ, Ahn, J & Hankenson, KD 2014, Bone Regeneration. in Translational Regenerative Medicine. Elsevier Inc., pp. 313-333. DOI: 10.1016/B978-0-12-410396-2.00024-4
Stewart S, Bryant SJ, Ahn J, Hankenson KD. Bone Regeneration. In Translational Regenerative Medicine. Elsevier Inc.2014. p. 313-333. Available from, DOI: 10.1016/B978-0-12-410396-2.00024-4
Stewart, Suzanne ; Bryant, Stephanie J. ; Ahn, Jaimo ; Hankenson, Kurt D./ Bone Regeneration. Translational Regenerative Medicine. Elsevier Inc., 2014. pp. 313-333
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