Bisphenol A and phthalates in utero and in childhood: association with child BMI z-score and adiposity

Tiffany C. Yang, Karen E. Peterson, John D. Meeker, Brisa N. Sánchez, Zhenzhen Zhang, Alejandra Cantoral, Maritsa Solano, Martha M. Tellez-Rojo

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Abstract

Objective To assess the relationship between in utero and concurrent child urinary exposures to bisphenol A (BPA) and phthalates with BMI z-score, waist circumference, and sum of triceps and subscapular skinfold thickness in Mexican children. Methods Among participants (N=249) from the Early Life Exposure in Mexico to ENvironmental Toxicants study, we evaluated associations between maternal third trimester and concurrent urinary BPA and individual and summed phthalates metabolites (∑Di(2-ethylhexyl phthalate), ∑high molecular weight, ∑low molecular weight) with measures of weight status and adiposity in children aged 8–14 years. Linear regressions with specific-gravity corrected and natural log-transformed urinary concentrations were estimated, adjusting for covariates. Effect modification by sex was explored. Results Prenatal urinary exposure to monobenzyl phthalate (MBzP) was inversely associated with child's BMI z-score (β=−0.21, 95%CI: −0.41, −0.02) and child urinary exposure to mono(2-ethylhexyl)phthalate (MEHP) was inversely associated with waist circumference (β=−1.85, 95%CI: −3.36, −0.35) and sum of skinfold thicknesses (β=−2.08, 95%CI: −3.80, −0.37) after adjusting for confounders. In the childhood exposure period, sex modified the relationships with BPA, MEHP, MBzP, monoethyl phthalate (MEP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono(2-ethyl-5-carboxypentyl) phthalate (MECPP). In girls, increased BPA exposure was positively associated with sum of skinfold thickness (β=3.47, 95%CI: 0.05, 6.40) while increased MEHP was inversely associated with sum of skinfold thicknesses in boys (β=−2.95, 95%CI: −5.08, −0.82); these results remained in sensitivity analyses after excluding children who had initiated pubertal development (Tanner stage >1 for pubic hair). We did not observe relationships between summed phthalates metabolites at any exposure period with outcome measures. Conclusion Our results identified associations between urinary BPA and phthalates metabolites with measures of weight status and adiposity that differed by timing of exposure, sex, and pubertal status. Additional studies are needed to explore how associations may differ between those who are pre- and post-pubertal.

LanguageEnglish (US)
Pages326-333
Number of pages8
JournalEnvironmental Research
Volume156
DOIs
StatePublished - Jan 1 2017

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phthalate
Adiposity
Skinfold Thickness
Metabolites
Waist Circumference
Weights and Measures
Molecular weight
Molecular Weight
metabolite
Specific Gravity
Linear regression
Density (specific gravity)
Third Pregnancy Trimester
Mexico
phthalic acid
bisphenol A
Hair
Linear Models
Mothers
Outcome Assessment (Health Care)

Keywords

  • Adiposity
  • Adolescence
  • Bisphenol A
  • BMI
  • Phthalates

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this

Bisphenol A and phthalates in utero and in childhood : association with child BMI z-score and adiposity. / Yang, Tiffany C.; Peterson, Karen E.; Meeker, John D.; Sánchez, Brisa N.; Zhang, Zhenzhen; Cantoral, Alejandra; Solano, Maritsa; Tellez-Rojo, Martha M.

In: Environmental Research, Vol. 156, 01.01.2017, p. 326-333.

Research output: Contribution to journalArticle

Yang, Tiffany C. ; Peterson, Karen E. ; Meeker, John D. ; Sánchez, Brisa N. ; Zhang, Zhenzhen ; Cantoral, Alejandra ; Solano, Maritsa ; Tellez-Rojo, Martha M./ Bisphenol A and phthalates in utero and in childhood : association with child BMI z-score and adiposity. In: Environmental Research. 2017 ; Vol. 156. pp. 326-333
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title = "Bisphenol A and phthalates in utero and in childhood: association with child BMI z-score and adiposity",
abstract = "Objective To assess the relationship between in utero and concurrent child urinary exposures to bisphenol A (BPA) and phthalates with BMI z-score, waist circumference, and sum of triceps and subscapular skinfold thickness in Mexican children. Methods Among participants (N=249) from the Early Life Exposure in Mexico to ENvironmental Toxicants study, we evaluated associations between maternal third trimester and concurrent urinary BPA and individual and summed phthalates metabolites (∑Di(2-ethylhexyl phthalate), ∑high molecular weight, ∑low molecular weight) with measures of weight status and adiposity in children aged 8–14 years. Linear regressions with specific-gravity corrected and natural log-transformed urinary concentrations were estimated, adjusting for covariates. Effect modification by sex was explored. Results Prenatal urinary exposure to monobenzyl phthalate (MBzP) was inversely associated with child's BMI z-score (β=−0.21, 95{\%}CI: −0.41, −0.02) and child urinary exposure to mono(2-ethylhexyl)phthalate (MEHP) was inversely associated with waist circumference (β=−1.85, 95{\%}CI: −3.36, −0.35) and sum of skinfold thicknesses (β=−2.08, 95{\%}CI: −3.80, −0.37) after adjusting for confounders. In the childhood exposure period, sex modified the relationships with BPA, MEHP, MBzP, monoethyl phthalate (MEP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono(2-ethyl-5-carboxypentyl) phthalate (MECPP). In girls, increased BPA exposure was positively associated with sum of skinfold thickness (β=3.47, 95{\%}CI: 0.05, 6.40) while increased MEHP was inversely associated with sum of skinfold thicknesses in boys (β=−2.95, 95{\%}CI: −5.08, −0.82); these results remained in sensitivity analyses after excluding children who had initiated pubertal development (Tanner stage >1 for pubic hair). We did not observe relationships between summed phthalates metabolites at any exposure period with outcome measures. Conclusion Our results identified associations between urinary BPA and phthalates metabolites with measures of weight status and adiposity that differed by timing of exposure, sex, and pubertal status. Additional studies are needed to explore how associations may differ between those who are pre- and post-pubertal.",
keywords = "Adiposity, Adolescence, Bisphenol A, BMI, Phthalates",
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T1 - Bisphenol A and phthalates in utero and in childhood

T2 - Environmental Research

AU - Yang,Tiffany C.

AU - Peterson,Karen E.

AU - Meeker,John D.

AU - Sánchez,Brisa N.

AU - Zhang,Zhenzhen

AU - Cantoral,Alejandra

AU - Solano,Maritsa

AU - Tellez-Rojo,Martha M.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objective To assess the relationship between in utero and concurrent child urinary exposures to bisphenol A (BPA) and phthalates with BMI z-score, waist circumference, and sum of triceps and subscapular skinfold thickness in Mexican children. Methods Among participants (N=249) from the Early Life Exposure in Mexico to ENvironmental Toxicants study, we evaluated associations between maternal third trimester and concurrent urinary BPA and individual and summed phthalates metabolites (∑Di(2-ethylhexyl phthalate), ∑high molecular weight, ∑low molecular weight) with measures of weight status and adiposity in children aged 8–14 years. Linear regressions with specific-gravity corrected and natural log-transformed urinary concentrations were estimated, adjusting for covariates. Effect modification by sex was explored. Results Prenatal urinary exposure to monobenzyl phthalate (MBzP) was inversely associated with child's BMI z-score (β=−0.21, 95%CI: −0.41, −0.02) and child urinary exposure to mono(2-ethylhexyl)phthalate (MEHP) was inversely associated with waist circumference (β=−1.85, 95%CI: −3.36, −0.35) and sum of skinfold thicknesses (β=−2.08, 95%CI: −3.80, −0.37) after adjusting for confounders. In the childhood exposure period, sex modified the relationships with BPA, MEHP, MBzP, monoethyl phthalate (MEP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono(2-ethyl-5-carboxypentyl) phthalate (MECPP). In girls, increased BPA exposure was positively associated with sum of skinfold thickness (β=3.47, 95%CI: 0.05, 6.40) while increased MEHP was inversely associated with sum of skinfold thicknesses in boys (β=−2.95, 95%CI: −5.08, −0.82); these results remained in sensitivity analyses after excluding children who had initiated pubertal development (Tanner stage >1 for pubic hair). We did not observe relationships between summed phthalates metabolites at any exposure period with outcome measures. Conclusion Our results identified associations between urinary BPA and phthalates metabolites with measures of weight status and adiposity that differed by timing of exposure, sex, and pubertal status. Additional studies are needed to explore how associations may differ between those who are pre- and post-pubertal.

AB - Objective To assess the relationship between in utero and concurrent child urinary exposures to bisphenol A (BPA) and phthalates with BMI z-score, waist circumference, and sum of triceps and subscapular skinfold thickness in Mexican children. Methods Among participants (N=249) from the Early Life Exposure in Mexico to ENvironmental Toxicants study, we evaluated associations between maternal third trimester and concurrent urinary BPA and individual and summed phthalates metabolites (∑Di(2-ethylhexyl phthalate), ∑high molecular weight, ∑low molecular weight) with measures of weight status and adiposity in children aged 8–14 years. Linear regressions with specific-gravity corrected and natural log-transformed urinary concentrations were estimated, adjusting for covariates. Effect modification by sex was explored. Results Prenatal urinary exposure to monobenzyl phthalate (MBzP) was inversely associated with child's BMI z-score (β=−0.21, 95%CI: −0.41, −0.02) and child urinary exposure to mono(2-ethylhexyl)phthalate (MEHP) was inversely associated with waist circumference (β=−1.85, 95%CI: −3.36, −0.35) and sum of skinfold thicknesses (β=−2.08, 95%CI: −3.80, −0.37) after adjusting for confounders. In the childhood exposure period, sex modified the relationships with BPA, MEHP, MBzP, monoethyl phthalate (MEP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono(2-ethyl-5-carboxypentyl) phthalate (MECPP). In girls, increased BPA exposure was positively associated with sum of skinfold thickness (β=3.47, 95%CI: 0.05, 6.40) while increased MEHP was inversely associated with sum of skinfold thicknesses in boys (β=−2.95, 95%CI: −5.08, −0.82); these results remained in sensitivity analyses after excluding children who had initiated pubertal development (Tanner stage >1 for pubic hair). We did not observe relationships between summed phthalates metabolites at any exposure period with outcome measures. Conclusion Our results identified associations between urinary BPA and phthalates metabolites with measures of weight status and adiposity that differed by timing of exposure, sex, and pubertal status. Additional studies are needed to explore how associations may differ between those who are pre- and post-pubertal.

KW - Adiposity

KW - Adolescence

KW - Bisphenol A

KW - BMI

KW - Phthalates

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