Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites

Russ Hauser, John D. Meeker, Susan Duty, Manori J. Silva, Antonia M. Calafat

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Phthalates are multifunctional chemicals used in a variety of consumer, medical, and personal care products. Previously, we reported dose-response associations of decreased semen quality with urinary concentrations of monobutyl phthalate (MBP) and monobenzyl (MBzP) phthalate, which are metabolites of dibutyl phthalate and butylbenzyl phthalate, respectively. The present study extends our work in a larger sample of men and includes measurements of di(2-ethylhexyl) phthalate (DEHP) oxidative metabolites. METHODS: Between January 2000 and May 2004, we recruited 463 male partners of subfertile couples who presented for semen analysis to the Massachusetts General Hospital. Semen parameters were dichotomized based on World Health Organization reference values for sperm concentration (

LanguageEnglish (US)
Pages682-691
Number of pages10
JournalEpidemiology
Volume17
Issue number6
DOIs
StatePublished - Nov 2006

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Semen Analysis
Dibutyl Phthalate
Semen
General Hospitals
Spermatozoa
Reference Values
phthalic acid

ASJC Scopus subject areas

  • Epidemiology

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Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites. / Hauser, Russ; Meeker, John D.; Duty, Susan; Silva, Manori J.; Calafat, Antonia M.

In: Epidemiology, Vol. 17, No. 6, 11.2006, p. 682-691.

Research output: Contribution to journalArticle

Hauser, Russ ; Meeker, John D. ; Duty, Susan ; Silva, Manori J. ; Calafat, Antonia M./ Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites. In: Epidemiology. 2006 ; Vol. 17, No. 6. pp. 682-691
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