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  • 14 Similar Profiles
Neoplasms Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Ubiquitin-Protein Ligases Medicine & Life Sciences
Genes Medicine & Life Sciences
Proteins Medicine & Life Sciences
Growth Medicine & Life Sciences
Cullin Proteins Medicine & Life Sciences
Carcinogenesis Medicine & Life Sciences

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Grants 2004 2021

Research Output 1987 2017

A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation

Zhou, H., Lu, J., Liu, L., Bernard, D., Yang, C. Y., Fernandez-Salas, E., Chinnaswamy, K., Layton, S., Stuckey, J., Yu, Q., Zhou, W., Pan, Z., Sun, Y. & Wang, S. Dec 1 2017 In : Nature Communications. 8, 1, 1150

Research output: Research - peer-reviewArticle

Cullin Proteins

Inhibition of Neddylation Modification Sensitizes Pancreatic Cancer Cells to Gemcitabine

Li, H., Zhou, W., Li, L., Wu, J., Liu, X., Zhao, L., Jia, L. & Sun, Y. Jun 1 2017 In : Neoplasia (United States). 19, 6, p. 509-518 10 p.

Research output: Research - peer-reviewArticle

Pancreatic Neoplasms
((1S,2S,4R)-4-(4-((1S)-2,3-dihydro-1H-inden-1-ylamino)-7H-pyrrolo(2,3-d)pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulphamate
2 Citations

Neddylation E2 UBE2F promotes the survival of lung cancer cells by activating CRL5 to degrade NOXA via the K11 linkage

Zhou, W., Xu, J., Li, H., Xu, M., Chen, Z. J., Wei, W., Pan, Z. & Sun, Y. Feb 15 2017 In : Clinical Cancer Research. 23, 4, p. 1104-1116 13 p.

Research output: Research - peer-reviewArticle

Cullin Proteins
Lung Neoplasms

Smurf1 regulates lung cancer cell growth and migration through interaction with and ubiquitination of PIPKI

Li, H., Xiao, N., Wang, Y., Wang, R., Chen, Y., Pan, W., Liu, D., Li, S., Sun, J., Zhang, K., Sun, Y. & Ge, X. Oct 12 2017 In : Oncogene. 36, 41, p. 5668-5680 13 p.

Research output: Research - peer-reviewArticle

Cell Movement
Lung Neoplasms
2 Citations

The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor

Xu, J., Zhou, W., Yang, F., Chen, G., Li, H., Zhao, Y., Liu, P., Li, H., Tan, M., Xiong, X. & Sun, Y. Jan 16 2017 In : Nature Communications. 8, 14002

Research output: Research - peer-reviewArticle

beta-Transducin Repeat-Containing Proteins