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  • 13 Similar Profiles
Neoplasms Medicine & Life Sciences
Proteins Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Ligands Medicine & Life Sciences
Molecules Chemical Compounds
Cell Line Medicine & Life Sciences
Cerebellar Ataxia Chemical Compounds
Castration Chemical Compounds

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Grants 2001 2021

Research Output 1991 2017

1 Citations

A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination

Wang, X., Cao, W., Zhang, J., Yan, M., Xu, Q., Wu, X., Wan, L., Zhang, Z., Zhang, C., Qin, X., Xiao, M., Ye, D., Liu, Y., Han, Z., Wang, S., Mao, L., Wei, W. & Chen, W. May 2 2017 In : EMBO Journal. 36, 9, p. 1243-1260 18 p.

Research output: Contribution to journalArticle

Ubiquitination
Neoplasms
Proteins
Contraception Behavior
Acids
Polycomb Repressive Complex 2
Embryonic Development
Proteins
Epigenomics
Heterografts

Current Medicinal Chemistry Research in India: Progress and Opportunities

Georg, G. I. & Wang, S. Mar 9 2017 In : Journal of Medicinal Chemistry. 60, 5, p. 1619 1 p.

Research output: Contribution to journalEditorial

1 Citations

Discovery of 4-((3′R,4′S,5′R)-6-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development

Aguilar, A., Lu, J., Liu, L., Du, D., Bernard, D., McEachern, D., Przybranowski, S., Li, X., Luo, R., Wen, B., Sun, D., Wang, H., Wen, J., Wang, G., Zhai, Y., Guo, M., Yang, D. & Wang, S. Apr 13 2017 In : Journal of Medicinal Chemistry. 60, 7, p. 2819-2839 21 p.

Research output: Contribution to journalArticle

Carboxylic Acids
Neoplasms
Clinical Trials, Phase I
Structure-Activity Relationship
Carbon

Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction

Karatas, H., Li, Y., Liu, L., Ji, J., Lee, S., Chen, Y., Yang, J., Huang, L., Bernard, D., Xu, J., Townsend, E. C., Cao, F., Ran, X., Li, X., Wen, B., Sun, D., Stuckey, J. A., Lei, M., Dou, Y. & Wang, S. Jun 22 2017 In : Journal of Medicinal Chemistry. 60, 12, p. 4818-4839 22 p.

Research output: Contribution to journalArticle

Myeloid-Lymphoid Leukemia Protein
Peptidomimetics
Tertiary Protein Structure
Leukemia
Proteins