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  • 11 Similar Profiles
Neoplasms Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Proteins Medicine & Life Sciences
Molecules Chemical Compounds
Ligands Medicine & Life Sciences
Gossypol Medicine & Life Sciences
X-Linked Inhibitor of Apoptosis Protein Medicine & Life Sciences
Protein Kinase C Medicine & Life Sciences

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Grants 1997 2022

Research Output 1991 2018

Cyclic Peptidic Mimetics of Apollo Peptides Targeting Telomeric Repeat Binding Factor 2 (TRF2) and Apollo Interaction

Chen, X., Liu, L., Chen, Y., Yang, Y., Yang, C. Y., Guo, T., Lei, M., Sun, H. & Wang, S. May 10 2018 In : ACS Medicinal Chemistry Letters. 9, 5, p. 507-511 5 p.

Research output: Contribution to journalArticle

Unsaturated polymers
Telomere
Peptides
Phosphodiesterase I
DNA Damage

Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein–Protein Interaction

Xu, S., Aguilar, A., Xu, T., Zheng, K., Huang, L., Stuckey, J., Chinnaswamy, K., Bernard, D., Fernández-Salas, E., Liu, L., Wang, M., McEachern, D., Przybranowski, S., Foster, C. & Wang, S. Feb 5 2018 In : Angewandte Chemie - International Edition. 57, 6, p. 1601-1605 5 p.

Research output: Contribution to journalArticle

Gene expression
Mass spectrometry
Genes
Crystal structure
Proteins
10 Citations

Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression

Zhou, B., Hu, J., Xu, F., Chen, Z., Bai, L., Fernandez-Salas, E., Lin, M., Liu, L., Yang, C. Y., Zhao, Y., McEachern, D., Przybranowski, S., Wen, B., Sun, D. & Wang, S. Jan 25 2018 In : Journal of medicinal chemistry. 61, 2, p. 462-481 20 p.

Research output: Contribution to journalArticle

Proteolysis
Neoplasms
Proteins
Heterografts
Epigenomics
2 Citations

High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction

Zhou, H., Zhou, W., Zhou, B., Liu, L., Chern, T. R., Chinnaswamy, K., Lu, J., Bernard, D., Yang, C. Y., Li, S., Wang, M., Stuckey, J., Sun, Y. & Wang, S. Mar 8 2018 In : Journal of medicinal chemistry. 61, 5, p. 1934-1950 17 p.

Research output: Contribution to journalArticle

Cullin Proteins
Peptidomimetics
Proteins
Ligases
Peptides
4 Citations

A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination

Wang, X., Cao, W., Zhang, J., Yan, M., Xu, Q., Wu, X., Wan, L., Zhang, Z., Zhang, C., Qin, X., Xiao, M., Ye, D., Liu, Y., Han, Z., Wang, S., Mao, L., Wei, W. & Chen, W. May 2 2017 In : EMBO Journal. 36, 9, p. 1243-1260 18 p.

Research output: Contribution to journalArticle

Ubiquitination
Corrosion inhibitors
Tumors
Degradation
Proteins