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  • 8 Similar Profiles
Neoplasms Medicine & Life Sciences
Proteins Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Ligands Medicine & Life Sciences
Cell Line Medicine & Life Sciences
Protein Kinase C Medicine & Life Sciences
Peptides Medicine & Life Sciences
Gossypol Medicine & Life Sciences

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Grants 2001 2021

Research Output 1991 2017

Polycomb Repressive Complex 2
Proteins
Epigenomics
Heterografts
Lymphoma

Discovery of 4-((3′R,4′S,5′R)-6-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development

Aguilar, A., Lu, J., Liu, L., Du, D., Bernard, D., McEachern, D., Przybranowski, S., Li, X., Luo, R., Wen, B., Sun, D., Wang, H., Wen, J., Wang, G., Zhai, Y., Guo, M., Yang, D. & Wang, S. Apr 13 2017 In : Journal of Medicinal Chemistry. 60, 7, p. 2819-2839 21 p.

Research output: Contribution to journalArticle

Carboxylic Acids
Neoplasms
Clinical Trials, Phase I
Structure-Activity Relationship
Carbon

Induction of p53 suppresses chronic myeloid leukemia

Peterson, L. F., Lo, M. C., Liu, Y., Giannola, D., Mitrikeska, E., Donato, N. J., Johnson, C. N., Wang, S., Mercer, J. & Talpaz, M. Jan 13 2017 In : Leukemia and Lymphoma. p. 1-14 14 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Philadelphia Chromosome
Myeloid Cells
Cell Cycle

The Ecstasy and Agony of Assay Interference Compounds

Aldrich, C., Bertozzi, C., Georg, G. I., Kiessling, L., Lindsley, C., Liotta, D., Merz, K. M., Schepartz, A. & Wang, S. Mar 23 2017 In : Journal of Medicinal Chemistry. 60, 6, p. 2165-2168 4 p.

Research output: Contribution to journalEditorial

The Ecstasy and Agony of Assay Interference Compounds

Aldrich, C., Bertozzi, C., Georg, G. I., Kiessling, L., Lindsley, C., Liotta, D., Merz, K. M., Schepartz, A. & Wang, S. Mar 17 2017 In : ACS Chemical Biology. 12, 3, p. 575-578 4 p.

Research output: Contribution to journalReview article