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  • 12 Similar Profiles
Neoplasms Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Proteins Medicine & Life Sciences
Molecules Chemical Compounds
Ligands Medicine & Life Sciences
Gossypol Medicine & Life Sciences
X-Linked Inhibitor of Apoptosis Protein Medicine & Life Sciences
Protein Kinase C Medicine & Life Sciences

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Grants 1997 2022

Research Output 1991 2018

Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein–Protein Interaction

Xu, S., Aguilar, A., Xu, T., Zheng, K., Huang, L., Stuckey, J., Chinnaswamy, K., Bernard, D., Fernández-Salas, E., Liu, L., Wang, M., McEachern, D., Przybranowski, S., Foster, C. & Wang, S. Feb 5 2018 In : Angewandte Chemie - International Edition. 57, 6, p. 1601-1605 5 p.

Research output: Contribution to journalArticle

Gene expression
Mass spectrometry
Genes
Crystal structure
Proteins
3 Citations

Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression

Zhou, B., Hu, J., Xu, F., Chen, Z., Bai, L., Fernandez-Salas, E., Lin, M., Liu, L., Yang, C. Y., Zhao, Y., McEachern, D., Przybranowski, S., Wen, B., Sun, D. & Wang, S. Jan 25 2018 In : Journal of Medicinal Chemistry. 61, 2, p. 462-481 20 p.

Research output: Contribution to journalArticle

Proteolysis
Neoplasms
Proteins
Heterografts
Epigenomics
4 Citations

A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination

Wang, X., Cao, W., Zhang, J., Yan, M., Xu, Q., Wu, X., Wan, L., Zhang, Z., Zhang, C., Qin, X., Xiao, M., Ye, D., Liu, Y., Han, Z., Wang, S., Mao, L., Wei, W. & Chen, W. May 2 2017 In : EMBO Journal. 36, 9, p. 1243-1260 18 p.

Research output: Contribution to journalArticle

Ubiquitination
Corrosion inhibitors
Tumors
Degradation
Proteins
Polycomb Repressive Complex 2
Embryonic Development
Epigenomics
Proteins
Heterografts
2 Citations

A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation

Zhou, H., Lu, J., Liu, L., Bernard, D., Yang, C. Y., Fernandez-Salas, E., Chinnaswamy, K., Layton, S., Stuckey, J., Yu, Q., Zhou, W., Pan, Z., Sun, Y. & Wang, S. Dec 1 2017 In : Nature Communications. 8, 1, 1150

Research output: Contribution to journalArticle

Cullin Proteins
inhibitors
proteins
Molecules
molecules