Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 4 Similar Profiles
Mutation Medicine & Life Sciences
Acute Myeloid Leukemia Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Mitogen-Activated Protein Kinase Kinases Medicine & Life Sciences
Cells Chemical Compounds
Hematopoietic Stem Cells Medicine & Life Sciences
Growth Medicine & Life Sciences

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Grants 2009 2021

Research Output 2005 2017

  • 425 Citations
  • 9 Scopus h-Index
  • 11 Article
  • 1 Comment/debate
3 Citations

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer

Burgess, M. R. , Hwang, E. , Mroue, R. , Bielski, C. M. , Wandler, A. M. , Huang, B. J. , Firestone, A. J. , Young, A. , Lacap, J. A. , Crocker, L. , Asthana, S. , Davis, E. M. , Xu, J. , Akagi, K. , Le Beau, M. M. , Li, Q. , Haley, B. , Stokoe, D. , Sampath, D. , Taylor, B. S. & 2 others Evangelista, M. & Shannon, K. Feb 23 2017 In : Cell. 168, 5, p. 817-829.e15

Research output: Research - peer-reviewArticle

Allelic Imbalance
Mitogen-Activated Protein Kinase Kinases
Phosphotransferases
Neoplasms
Therapeutics

The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

Fenouille, N. , Bassil, C. F. , Ben-Sahra, I. , Benajiba, L. , Alexe, G. , Ramos, A. , Pikman, Y. , Conway, A. S. , Burgess, M. R. , Li, Q. , Luciano, F. , Auberger, P. , Galinsky, I. , Deangelo, D. J. , Stone, R. M. , Zhang, Y. , Perkins, A. S. , Shannon, K. , Hemann, M. T. , Puissant, A. & 1 others Stegmaier, K. Mar 1 2017 In : Nature Medicine. 23, 3, p. 301-313 13 p.

Research output: Research - peer-reviewArticle

Creatine
Creatine Kinase
Metabolism
Small Interfering RNA
Arginine
26 Citations

Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia

Dail, M., Wong, J., Lawrence, J., O'Connor, D., Nakitandwe, J., Chen, S. C., Xu, J., Lee, L. B., Akagi, K., Li, Q., Aster, J. C., Pear, W. S., Downing, J. R., Sampath, D. & Shannon, K. Jul 20 2014 In : Nature. 513, 7519, p. 512-516 5 p.

Research output: Research - peer-reviewArticle

T-Cell Leukemia
1-Phosphatidylinositol 4-Kinase
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Clone Cells
Mutation
23 Citations

Preclinical efficacy of MEK inhibition in NRAS-mutant AML

Burgess, M. R., Hwang, E., Firestone, A. J., Huang, T., Xu, J., Zuber, J., Bohin, N., Wen, T., Kogan, S. C., Haigis, K. M., Sampath, D., Lowe, S., Shannon, K. & Li, Q. Dec 18 2014 In : Blood. 124, 26, p. 3947-3955 9 p.

Research output: Research - peer-reviewArticle

Mitogen-Activated Protein Kinase Kinases
Hematopoietic Stem Cells
Acute Myeloid Leukemia
PD 0325901
Mutation
25 Citations

Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation

Xu, J., Haigis, K. M., Firestone, A. J., McNerney, M. E., Li, Q., Davis, E., Chen, S. C., Nakitandwe, J., Downing, J., Jacks, T., Le Beau, M. M. & Shannon, K. Sep 2013 In : Cancer Discovery. 3, 9, p. 993-1001 9 p.

Research output: Research - peer-reviewArticle

Oncogenes
Neoplasms
Growth
Mitogen-Activated Protein Kinase Kinases
Therapeutics