Fingerprint Fingerprint is based on mining the text of the persons scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 7 Similar Profiles
Neoplasms Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Inhibitor of Apoptosis Proteins Medicine & Life Sciences
Butyrates Medicine & Life Sciences
Growth Medicine & Life Sciences
Zinc Fingers Medicine & Life Sciences
Proteins Medicine & Life Sciences
Cells Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2009 2022

Research Output 1997 2018

  • 1498 Citations
  • 25 h-Index
  • 42 Article
  • 4 Review article
  • 2 Comment/debate
4 Citations

Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression

Zhou, B., Hu, J., Xu, F., Chen, Z., Bai, L., Fernandez-Salas, E., Lin, M., Liu, L., Yang, C. Y., Zhao, Y., McEachern, D., Przybranowski, S., Wen, B., Sun, D. & Wang, S. Jan 25 2018 In : Journal of medicinal chemistry. 61, 2, p. 462-481 20 p.

Research output: Contribution to journalArticle

Proteolysis
Neoplasms
Proteins
Heterografts
Epigenomics

Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor

Zhao, Y., Bai, L., Liu, L., McEachern, D., Stuckey, J. A., Meagher, J. L., Yang, C. Y., Ran, X., Zhou, B., Hu, Y., Li, X., Wen, B., Zhao, T., Li, S., Sun, D. & Wang, S. May 11 2017 In : Journal of medicinal chemistry. 60, 9, p. 3887-3901 15 p.

Research output: Contribution to journalArticle

Leukemia
Proteins
Triple Negative Breast Neoplasms
Heterografts
Pharmacokinetics
10 Citations

Targeted degradation of BET proteins in triple-negative breast cancer

Bai, L. , Zhou, B. , Yang, C. Y. , Ji, J. , McEachern, D. , Przybranowski, S. , Jiang, H. , Hu, J. , Xu, F. , Zhao, Y. , Liu, L. , Fernandez-Salas, E. , Xu, J. , Dou, Y. , Wen, B. , Sun, D. , Meagher, J. , Stuckey, J. , Hayes, D. F. , Li, S. & 2 others Ellis, M. J. & Wang, S. May 1 2017 In : Cancer Research. 77, 9, p. 2476-2487 12 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Proteolysis
Apoptosis
Down-Regulation
Genes
3 Citations

Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors

Yang, C. Y., Phillips, J. G., Stuckey, J. A., Bai, L., Sun, H., Delproposto, J., Brown, W. C. & Chinnaswamy, K. Dec 8 2016 In : ACS Medicinal Chemistry Letters. 7, 12, p. 1092-1096 5 p.

Research output: Contribution to journalArticle

Complement Factor D
Hydrogen
Hydrogen bonds
Amides
Alternative Complement Pathway
27 Citations

Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors

Ran, X., Zhao, Y., Liu, L., Bai, L., Yang, C. Y., Zhou, B., Meagher, J. L., Chinnaswamy, K., Stuckey, J. A. & Wang, S. Jun 25 2015 In : Journal of medicinal chemistry. 58, 12, p. 4927-4939 13 p.

Research output: Contribution to journalArticle

Proteins
Leukemia
gamma-carboline
Neoplasms
Cell Line