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  • 7 Similar Profiles
Neoplasms Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Inhibitor of Apoptosis Proteins Medicine & Life Sciences
Butyrates Medicine & Life Sciences
Growth Medicine & Life Sciences
Zinc Fingers Medicine & Life Sciences
Proteins Medicine & Life Sciences
Cells Chemical Compounds

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Grants 2009 2022

Research Output 1997 2018

  • 1498 Citations
  • 25 h-Index
  • 42 Article
  • 4 Review article
  • 2 Comment/debate
4 Citations

Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression

Zhou, B., Hu, J., Xu, F., Chen, Z., Bai, L., Fernandez-Salas, E., Lin, M., Liu, L., Yang, C. Y., Zhao, Y., McEachern, D., Przybranowski, S., Wen, B., Sun, D. & Wang, S. Jan 25 2018 In : Journal of medicinal chemistry. 61, 2, p. 462-481 20 p.

Research output: Contribution to journalArticle


Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor

Zhao, Y., Bai, L., Liu, L., McEachern, D., Stuckey, J. A., Meagher, J. L., Yang, C. Y., Ran, X., Zhou, B., Hu, Y., Li, X., Wen, B., Zhao, T., Li, S., Sun, D. & Wang, S. May 11 2017 In : Journal of medicinal chemistry. 60, 9, p. 3887-3901 15 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
10 Citations

Targeted degradation of BET proteins in triple-negative breast cancer

Bai, L. , Zhou, B. , Yang, C. Y. , Ji, J. , McEachern, D. , Przybranowski, S. , Jiang, H. , Hu, J. , Xu, F. , Zhao, Y. , Liu, L. , Fernandez-Salas, E. , Xu, J. , Dou, Y. , Wen, B. , Sun, D. , Meagher, J. , Stuckey, J. , Hayes, D. F. , Li, S. & 2 others Ellis, M. J. & Wang, S. May 1 2017 In : Cancer Research. 77, 9, p. 2476-2487 12 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
3 Citations

Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors

Yang, C. Y., Phillips, J. G., Stuckey, J. A., Bai, L., Sun, H., Delproposto, J., Brown, W. C. & Chinnaswamy, K. Dec 8 2016 In : ACS Medicinal Chemistry Letters. 7, 12, p. 1092-1096 5 p.

Research output: Contribution to journalArticle

Complement Factor D
Hydrogen bonds
Alternative Complement Pathway
27 Citations

Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors

Ran, X., Zhao, Y., Liu, L., Bai, L., Yang, C. Y., Zhou, B., Meagher, J. L., Chinnaswamy, K., Stuckey, J. A. & Wang, S. Jun 25 2015 In : Journal of medicinal chemistry. 58, 12, p. 4927-4939 13 p.

Research output: Contribution to journalArticle

Cell Line