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  • 8 Similar Profiles
Neoplasms Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Proteins Medicine & Life Sciences
Growth Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Cells Chemical Compounds
Cell Line Medicine & Life Sciences
Butyrates Medicine & Life Sciences

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Grants 2009 2022

Research Output 1997 2017

  • 1424 Citations
  • 24 h-Index
  • 41 Article
  • 4 Review article
  • 2 Comment/debate

Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor

Zhao, Y., Bai, L., Liu, L., McEachern, D., Stuckey, J. A., Meagher, J. L., Yang, C. Y., Ran, X., Zhou, B., Hu, Y., Li, X., Wen, B., Zhao, T., Li, S., Sun, D. & Wang, S. May 11 2017 In : Journal of Medicinal Chemistry. 60, 9, p. 3887-3901 15 p.

Research output: Research - peer-reviewArticle

Triple Negative Breast Neoplasms
5 Citations

Targeted degradation of BET proteins in triple-negative breast cancer

Bai, L. , Zhou, B. , Yang, C. Y. , Ji, J. , McEachern, D. , Przybranowski, S. , Jiang, H. , Hu, J. , Xu, F. , Zhao, Y. , Liu, L. , Fernandez-Salas, E. , Xu, J. , Dou, Y. , Wen, B. , Sun, D. , Meagher, J. , Stuckey, J. , Hayes, D. F. , Li, S. & 2 others Ellis, M. J. & Wang, S. May 1 2017 In : Cancer Research. 77, 9, p. 2476-2487 12 p.

Research output: Research - peer-reviewArticle

Triple Negative Breast Neoplasms
2 Citations

Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors

Yang, C. Y., Phillips, J. G., Stuckey, J. A., Bai, L., Sun, H., Delproposto, J., Brown, W. C. & Chinnaswamy, K. Dec 8 2016 In : ACS Medicinal Chemistry Letters. 7, 12, p. 1092-1096 5 p.

Research output: Research - peer-reviewArticle

Complement Factor D
Hydrogen bonds
24 Citations

Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors

Ran, X., Zhao, Y., Liu, L., Bai, L., Yang, C. Y., Zhou, B., Meagher, J. L., Chinnaswamy, K., Stuckey, J. A. & Wang, S. Jun 25 2015 In : Journal of Medicinal Chemistry. 58, 12, p. 4927-4939 13 p.

Research output: Research - peer-reviewArticle

compound 18
25 Citations

BM-1197: A novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo

Bai, L., Chen, J., McEachern, D., Liu, L., Zhou, H., Aguilar, A. & Wang, S. Jun 5 2014 In : PLoS One. 9, 6, e99404

Research output: Research - peer-reviewArticle

lung neoplasms