Research Output 1991 2018

2018

Bone healing in an aged murine fracture model is characterized by sustained callus inflammation and decreased cell proliferation

Hebb, J. H., Ashley, J. W., McDaniel, L., Lopas, L. A., Tobias, J., Hankenson, K. D. & Ahn, J. Jan 1 2018 In : Journal of Orthopaedic Research. 36, 1, p. 149-158 10 p.

Research output: Contribution to journalArticle

Bone Regeneration
Bony Callus
Cell Proliferation
Inflammation
Bone and Bones
1 Citations

Chemokine receptor-7 (CCR7) deficiency leads to delayed development of joint damage and functional deficits in a murine model of osteoarthritis

Sambamurthy, N., Nguyen, V., Smalley, R., Xiao, R., Hankenson, K., Gan, J., Miller, R. E., Malfait, A. M., Dodge, G. R. & Scanzello, C. R. Mar 1 2018 In : Journal of Orthopaedic Research. 36, 3, p. 864-875 12 p.

Research output: Contribution to journalArticle

Tibial Meniscus
Chemokine Receptors
Osteoarthritis
Joints
Public Sector
2017

Ethical use of animal models in musculoskeletal research

Allen, M. J., Hankenson, K. D., Goodrich, L., Boivin, G. P. & von Rechenberg, B. Apr 1 2017 In : Journal of Orthopaedic Research. 35, 4, p. 740-751 12 p.

Research output: Contribution to journalArticle

Animal Models
Animal Welfare
Laboratory Animals
Research
Publications
1 Citations

Implicating candidate genes at GWAS signals by leveraging topologically associating domains

Way, G. P., Youngstrom, D. W., Hankenson, K. D., Greene, C. S. & Grant, S. F. A. Nov 1 2017 In : European Journal of Human Genetics. 25, 11, p. 1286-1289 4 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Genes
Bone Density
Genome
Inborn Genetic Diseases
1 Citations

Stimulating fracture healing in Ischemic environments: Does oxygen direct stem cell fate during fracture healing?

Miclau, K. R., Brazina, S. A., Bahney, C. S., Hankenson, K. D., Hunt, T. K., Marcucio, R. S. & Miclau, T. May 4 2017 In : Frontiers in Cell and Developmental Biology. 5, MAY, 45

Research output: Contribution to journalShort survey

Fracture Healing
Stem Cells
Oxygen
Chondrocytes
Osteoblasts

Stimulation of notch signaling in mouse osteoclast precursors

Kaur, G., Ahn, J., Hankenson, K. D. & Ashley, J. W. Feb 28 2017 In : Journal of Visualized Experiments. 2017, 120, e55234

Research output: Contribution to journalArticle

Osteoclasts
Ligands
Cultured Cells
Physiological Phenomena
Chemical activation

Wnt10b and Dkk-1 gene therapy differentially influenced trabecular bone architecture, soft tissue integrity, and osteophytosis in a skeletally mature rat model of osteoarthritis

Mason, J. B., Gurda, B. L., Hankenson, K. D., Harper, L. R., Carlson, C. S., Wilson, J. M. & Richardson, D. W. Nov 2 2017 In : Connective Tissue Research. 58, 6, p. 542-552 11 p.

Research output: Contribution to journalArticle

Gene therapy
Osteoarthritis
Genetic Therapy
Rats
Bone
2016
7 Citations

A computational model to explore the role of angiogenic impairment on endochondral ossification during fracture healing

OReilly, A., Hankenson, K. D. & Kelly, D. J. Oct 1 2016 In : Biomechanics and Modeling in Mechanobiology. 15, 5, p. 1279-1294 16 p.

Research output: Contribution to journalArticle

Fracture Healing
Osteogenesis
Computational Model
Cartilage
Oxygen
2 Citations

An Injured Psittacosaurus (Dinosauria: Ceratopsia) From the Yixian Formation (Liaoning, China): Implications for Psittacosaurus Biology

Hedrick, B. P., Gao, C., Tumarkin-Deratzian, A. R., Shen, C., Holloway, J. L., Zhang, F., Hankenson, K. D., Liu, S., Anné, J. & Dodson, P. Jul 1 2016 In : Anatomical Record. 299, 7, p. 897-906 10 p.

Research output: Contribution to journalArticle

micro-computed tomography
X-Ray Microtomography
Paleopathology
fibula
China
4 Citations

Jagged1 expression by osteoblast-lineage cells regulates trabecular bone mass and periosteal expansion in mice

Youngstrom, D. W., Dishowitz, M. I., Bales, C. B., Carr, E., Mutyaba, P. L., Kozloff, K. M., Shitaye, H., Hankenson, K. D. & Loomes, K. M. Oct 1 2016 In : Bone. 91, p. 64-74 11 p.

Research output: Contribution to journalArticle

Osteoblasts
Alagille Syndrome
Bone and Bones
Phenotype
Thigh
2 Citations

THBS2 Is a Candidate Modifier of Liver Disease Severity in Alagille Syndrome

Tsai, E. A., Gilbert, M. A., Grochowski, C. M., Underkoffler, L. A., Meng, H., Zhang, X., Wang, M. M., Shitaye, H., Hankenson, K. D., Piccoli, D., Lin, H., Kamath, B. M., Devoto, M., Spinner, N. B. & Loomes, K. M. Jan 1 2016 In : CMGH. 2, 5, p. 663-675.e2

Research output: Contribution to journalArticle

Alagille Syndrome
Liver Diseases
Bile Ducts
Genome-Wide Association Study
Liver
2015
42 Citations

Extracellular matrix networks in bone remodeling

Alford, A. I., Kozloff, K. M. & Hankenson, K. D. May 31 2015 In : International Journal of Biochemistry and Cell Biology. 65, p. 20-31 12 p., 4620

Research output: Contribution to journalArticle

Bone Remodeling
Extracellular Matrix
Bone
Osteoclasts
Bone and Bones
36 Citations

Extracellular signaling molecules to promote fracture healing and bone regeneration

Hankenson, K. D., Gagne, K. & Shaughnessy, M. Jan 1 2015 In : Advanced Drug Delivery Reviews. 94, p. 3-12 10 p.

Research output: Contribution to journalReview article

Bone Regeneration
Fracture Healing
Bone and Bones
Osteoblasts
Bone Morphogenetic Protein 7
32 Citations

Immunomodulation by mesenchymal stem cells combats the foreign body response to cell-laden synthetic hydrogels

Swartzlander, M. D., Blakney, A. K., Amer, L. D., Hankenson, K. D., Kyriakides, T. R. & Bryant, S. J. Jan 1 2015 In : Biomaterials. 41, p. 79-88 10 p.

Research output: Contribution to journalArticle

Artificial Cells
Hydrogels
Immunomodulation
Foreign Bodies
Stem cells
7 Citations

Mutation in osteoactivin promotes receptor activator of NFκB ligand (RANKL)-mediated osteoclast differentiation and survival but inhibits osteoclast function

Abdelmagid, S. M., Sondag, G. R., Moussa, F. M., Belcher, J. Y., Yu, B., Stinnett, H., Novak, K., Mbimba, T., Khol, M., Hankenson, K. D., Malcuit, C. & Safadi, F. F. Aug 14 2015 In : Journal of Biological Chemistry. 290, 33, p. 20128-20146 19 p.

Research output: Contribution to journalArticle

Osteoclasts
Osteogenesis
Ligands
Mutation
Bone
16 Citations

Notch Signaling Promotes Osteoclast Maturation and Resorptive Activity

Ashley, J. W., Ahn, J. & Hankenson, K. D. Nov 1 2015 In : Journal of Cellular Biochemistry. 116, 11, p. 2598-2609 12 p.

Research output: Contribution to journalArticle

Osteoclasts
Amyloid Precursor Protein Secretases
Osteogenesis
Ligands
11 Citations

Osseointegrative properties of electrospun hydroxyapatite-containing nanofibrous chitosan scaffolds

Frohbergh, M. E., Katsman, A., Mondrinos, M. J., Stabler, C. T., Hankenson, K. D., Oristaglio, J. T. & Lelkes, P. I. Jan 1 2015 In : Tissue Engineering - Part A. 21, 5-6, p. 970-981 12 p.

Research output: Contribution to journalArticle

Chitosan
Durapatite
Hydroxyapatite
Scaffolds
Stem cells
5 Citations

Osteopathology in the Equine Distal Phalanx Associated With the Development and Progression of Laminitis

Engiles, J. B., Galantino-Homer, H. L., Boston, R., McDonald, D., Dishowitz, M. & Hankenson, K. D. Jan 1 2015 In : Veterinary pathology. 52, 5, p. 928-944 17 p.

Research output: Contribution to journalArticle

laminitis
phalanges
Horses
horses
Hoof and Claw
15 Citations

Synergistic Effects of SDF-1α and BMP-2 Delivery from Proteolytically Degradable Hyaluronic Acid Hydrogels for Bone Repair

Holloway, J. L., Ma, H., Rai, R., Hankenson, K. D. & Burdick, J. A. Sep 1 2015 In : Macromolecular Bioscience. 15, 9, p. 1218-1223 6 p.

Research output: Contribution to journalArticle

Chemokine CXCL12
Hyaluronic acid
Bone Morphogenetic Protein 2
Hydrogels
Hyaluronic Acid
1 Citations

Thrombospondin-2 Expression during Retinal Vascular Development and Neovascularization

Fei, P., Palenski, T. L., Wang, S., Gurel, Z., Hankenson, K. D., Sorenson, C. M. & Sheibani, N. Sep 1 2015 In : Journal of Ocular Pharmacology and Therapeutics. 31, 7, p. 429-444 16 p.

Research output: Contribution to journalArticle

Retinal Neovascularization
Retinal Vessels
Green Fluorescent Proteins
Choroidal Neovascularization
Retina
2 Citations

Type III collagen modulates fracture callus bone formation and early remodeling

Miedel, E. L., Brisson, B. K., Hamilton, T., Gleason, H., Swain, G. P., Lopas, L., Dopkin, D., Perosky, J. E., Kozloff, K. M., Hankenson, K. D. & Volk, S. W. Jan 1 2015 In : Journal of Orthopaedic Research. 33, 5, p. 675-684 10 p.

Research output: Contribution to journalArticle

Collagen Type III
Bony Callus
Osteogenesis
Bone and Bones
X-Ray Microtomography
2014
8 Citations

A ChIP-seq-defined genome-wide map of MEF2C binding reveals inflammatory pathways associated with its role in bone density determination

Johnson, M. E., Deliard, S., Zhu, F., Xia, Q., Wells, A. D., Hankenson, K. D. & Grant, S. F. A. Jan 1 2014 In : Calcified Tissue International. 94, 4, p. 396-402 7 p.

Research output: Contribution to journalArticle

Bone Density
Transcription Factors
Genome-Wide Association Study
Genome
Genes
38 Citations

Biological perspectives of delayed fracture healing

Hankenson, K. D., Zimmerman, G. & Marcucio, R. Jan 1 2014 In : Injury. 45, SUPPL. 2

Research output: Contribution to journalArticle

Fracture Healing
Biological Phenomena
Bone Fractures
Biological Factors
Biomarkers

Bone Regeneration

Stewart, S., Bryant, S. J., Ahn, J. & Hankenson, K. D. Dec 2 2014 Translational Regenerative Medicine. Elsevier Inc., p. 313-333 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bone Regeneration
Bone and Bones
Fracture Healing
Debridement
Connective Tissue
14 Citations

Fractures in Geriatric Mice Show Decreased Callus Expansion and Bone Volume

Lopas, L. A., Belkin, N. S., Mutyaba, P. L., Gray, C. F., Hankenson, K. D. & Ahn, J. Jan 1 2014 In : Clinical Orthopaedics and Related Research. 472, 11, p. 3523-3532 10 p.

Research output: Contribution to journalArticle

Bony Callus
Geriatrics
Fracture Healing
Cartilage
Bone and Bones
15 Citations

Jagged1 immobilization to an osteoconductive polymer activates the Notch signaling pathway and induces osteogenesis

Dishowitz, M. I., Zhu, F., Sundararaghavan, H. G., Ifkovits, J. L., Burdick, J. A. & Hankenson, K. D. 2014 In : Journal of Biomedical Materials Research - Part A. 102, 5, p. 1558-1567 10 p.

Research output: Contribution to journalArticle

Polymers
Bone
Stem cells
Ligands
Bone Morphogenetic Proteins
15 Citations

Megakaryocytes are mechanically responsive and influence osteoblast proliferation and differentiation

Soves, C. P., Miller, J. D., Begun, D. L., Taichman, R. S., Hankenson, K. D. & Goldstein, S. A. Jan 1 2014 In : Bone. 66, p. 111-120 10 p.

Research output: Contribution to journalArticle

Megakaryocytes
Osteoblasts
Coculture Techniques
Osteocytes
Extremities
9 Citations

Mouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis

Brennan, T. A., Egan, K. P., Lindborg, C. M., Chen, Q., Sweetwyne, M. T., Hankenson, K. D., Xie, S. X., Johnson, F. B. & Pignolo, R. J. Jan 1 2014 In : DMM Disease Models and Mechanisms. 7, 5, p. 583-592 10 p.

Research output: Contribution to journalArticle

Telomere
Osteoporosis
Bone
Osteoblasts
Aging of materials
9 Citations

Notch signaling in mesenchymal stem cells harvested from geriatric mice

Mutyaba, P. L., Belkin, N. S., Lopas, L., Gray, C. F., Dopkin, D., Hankenson, K. D. & Ahn, J. 2014 In : Journal of Orthopaedic Trauma. 28, SUPPL. 1

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Geriatrics
Notch Receptors
Ligands
Fracture Healing
8 Citations

R-spondins: Novel matricellular regulators of the skeleton

Knight, M. N. & Hankenson, K. D. Jul 1 2014 In : Matrix Biology. 37, p. 157-161 5 p.

Research output: Contribution to journalArticle

Wnt Receptors
Furin
beta Catenin
Osteogenesis
Skeleton
10 Citations

Type III collagen regulates osteoblastogenesis and the quantity of trabecular bone

Volk, S. W., Shah, S. R., Cohen, A. J., Wang, Y., Brisson, B. K., Vogel, L. K., Hankenson, K. D. & Adams, S. L. Jan 1 2014 In : Calcified Tissue International. 94, 6, p. 621-631 11 p.

Research output: Contribution to journalArticle

Collagen Type III
Bone and Bones
Ehlers-Danlos Syndrome
Osteoblasts
Blood Vessels
2013
13 Citations

Brief report: Long-term functional engraftment of mesenchymal progenitor cells in a mouse model of accelerated aging

Singh, L., Brennan, T. A., Kim, J. H., Egan, K. P., McMillan, E. A., Chen, Q., Hankenson, K. D., Zhang, Y., Emerson, S. G., Johnson, F. B. & Pignolo, R. J. Mar 2013 In : Stem Cells. 31, 3, p. 607-611 5 p.

Research output: Contribution to journalArticle

Osteoblasts
Mesenchymal Stromal Cells
Bone Transplantation
Cell Aging
Telomere
17 Citations

Cyp1B1 expression promotes angiogenesis by suppressing NF-κB activity

Palenski, T. L., Gurel, Z., Sorenson, C. M., Hankenson, K. D. & Sheibani, N. Dec 1 2013 In : American Journal of Physiology - Cell Physiology. 305, 11

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Pericytes
Blood Vessels
Endothelial Cells
Morphogenesis
8 Citations

Disruption of thrombospondin-2 accelerates ischemic fracture healing

Miedel, E., Dishowitz, M. I., Myers, M. H., Dopkin, D., Yu, Y. Y., Miclau, T. S., Marcucio, R., Ahn, J. & Hankenson, K. D. Jun 2013 In : Journal of Orthopaedic Research. 31, 6, p. 935-943 9 p.

Research output: Contribution to journalArticle

Fracture Healing
Bone and Bones
thrombospondin 2
Blood Vessels
Phenotype
5 Citations

Multiple recombinant adeno-associated viral vector serotypes display persistent in vivo gene expression in vector-transduced rat stifle joints

Mason, J. B., Gurda, B. L., Engiles, J. B., Hankenson, K. D., Wilson, J. M. & Richardson, D. W. Jun 1 2013 In : Human Gene Therapy Methods. 24, 3, p. 185-194 10 p.

Research output: Contribution to journalArticle

Stifle
Joints
Gene Expression
Surface-Active Agents
Serogroup
27 Citations

Osteoblast-targeted suppression of PPARc increases osteogenesis through activation of mTOR signaling

Sun, H., Kim, J. K., Mortensen, R., Mutyaba, L. P., Hankenson, K. D. & Krebsbach, P. H. Oct 2013 In : Stem Cells. 31, 10, p. 2183-2192 10 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Sirolimus
Osteoblasts
Osteogenesis
Mesenchymal Stromal Cells
23 Citations

PKCδ is required for jagged-1 induction of human mesenchymal stem cell osteogenic differentiation

Zhu, F., Sweetwyne, M. T. & Hankenson, K. D. Jun 2013 In : Stem Cells. 31, 6, p. 1181-1192 12 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Protein Kinases
Cell Differentiation
Ligands
Alagille Syndrome
24 Citations

Systemic Inhibition of Canonical Notch Signaling Results in Sustained Callus Inflammation and Alters Multiple Phases of Fracture Healing

Dishowitz, M. I., Mutyaba, P. L., Takacs, J. D., Barr, A. M., Engiles, J. B., Ahn, J. & Hankenson, K. D. Jul 3 2013 In : PLoS ONE. 8, 7, e68726

Research output: Contribution to journalArticle

Fracture Healing
Bony Callus
Bone
callus
inflammation
21 Citations

The role of oxygen as a regulator of stem cell fate during fracture repair in TSP2-null mice

Burke, D., Dishowitz, M., Sweetwyne, M., Miedel, E., Hankenson, K. D. & Kelly, D. J. Oct 2013 In : Journal of Orthopaedic Research. 31, 10, p. 1585-1596 12 p.

Research output: Contribution to journalArticle

Stem Cells
Oxygen
Osteogenesis
Bony Callus
Fracture Healing
2012
6 Citations

A potential role for the myeloid lineage in leptin-regulated bone metabolism

Scheller, E. L., Song, J., Dishowitz, M. I., Hankenson, K. D. & Krebsbach, P. H. 2012 In : Hormone and Metabolic Research. 44, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Leptin
Metabolism
Bone
Bone and Bones
Bone Density
19 Citations

Effects of donor characteristics and ex vivo expansion on canine mesenchymal stem cell properties: Implications for MSC-based therapies

Volk, S. W., Wang, Y. & Hankenson, K. D. Dec 7 2012 In : Cell Transplantation. 21, 10, p. 2189-2200 12 p.

Research output: Contribution to journalArticle

Cell- and Tissue-Based Therapy
Stem cells
Mesenchymal Stromal Cells
Canidae
Bone
28 Citations

Notch signaling components are upregulated during both endochondral and intramembranous bone regeneration

Dishowitz, M. I., Terkhorn, S. P., Bostic, S. A. & Hankenson, K. D. Feb 2012 In : Journal of Orthopaedic Research. 30, 2, p. 296-303 8 p.

Research output: Contribution to journalArticle

Tibial Fractures
Bone Regeneration
Chondrogenesis
Bone and Bones
Fracture Healing

Notch signalling regulates osteoblastogenesis and bone regeneration

Dishowitz, M. I., Zhu, F., Dopkin, D., Bales, C. B., Loomes, K. M., Ahn, J. & Hankenson, K. D. Jan 1 2012 In : European Cells and Materials. 24, SUPPL. 1, 1 p.

Research output: Contribution to journalComment/debate

Bone Regeneration
Bone
44 Citations

The transcription factor osterix (SP7) regulates BMP6-induced human osteoblast differentiation

Zhu, F., Friedman, M. S., Luo, W., Woolf, P. & Hankenson, K. D. Jun 2012 In : Journal of Cellular Physiology. 227, 6, p. 2677-2685 9 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 6
Osteoblasts
Mesenchymal Stromal Cells
Transcription Factors
Genes
2011
120 Citations

Angiogenesis in bone regeneration

Hankenson, K. D., Dishowitz, M., Gray, C. & Schenker, M. Jun 1 2011 In : Injury. 42, 6, p. 556-561 6 p.

Research output: Contribution to journalReview article

Bone Regeneration
Blood Vessels
Bone and Bones
Fracture Healing
Bony Callus
13 Citations

Ectopic expression of Col2.3 and Col3.6 promoters in the brain and association with leptin signaling

Scheller, E. L., Leinninger, G. M., Hankenson, K. D., Myers, M. G. & Krebsbach, P. H. Aug 2011 In : Cells Tissues Organs. 194, 2-4, p. 268-273 6 p.

Research output: Contribution to journalArticle

Leptin
Third Ventricle
Lateral Hypothalamic Area
Brain
Transgenic Mice
20 Citations

Evaluation of equine peripheral blood apheresis product, bone marrow, and adipose tissue as sources of mesenchymal stem cells and their differentation potential

Ahern, B. J., Schaer, T. P., Terkhorn, S. P., Jackson, K. V., Mason, N. J. & Hankenson, K. D. Jan 2011 In : American Journal of Veterinary Research. 72, 1, p. 127-133 7 p.

Research output: Contribution to journalArticle

Blood Component Removal
Mesenchymal Stromal Cells
bone marrow
adipose tissue
Horses
184 Citations

Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation

Lin, G. L. & Hankenson, K. D. Dec 2011 In : Journal of Cellular Biochemistry. 112, 12, p. 3491-3501 11 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Osteoblasts
Stem cells
Mesenchymal Stromal Cells
Cell Differentiation
21 Citations

The Muenke syndrome mutation (FgfR3 P244R) causes cranial base shortening associated with growth plate dysfunction and premature perichondrial ossification in murine basicranial synchondroses

Laurita, J., Koyama, E., Chin, B., Taylor, J. A., Lakin, G. E., Hankenson, K. D., Bartlett, S. P. & Nah, H. D. Nov 2011 In : Developmental Dynamics. 240, 11, p. 2584-2596 13 p.

Research output: Contribution to journalArticle

Growth Plate
Skull Base
Osteogenesis
Chondrocytes
Mutation
7 Citations
Osteoblasts
Gene Expression Profiling
Profiling
Gene expression
Gene Expression