Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 11 Similar Profiles
Neoplasms Medicine & Life Sciences
Mitogen-Activated Protein Kinase Kinases Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Growth Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
Mitogen-Activated Protein Kinases Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
Proteins Chemical Compounds

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Grants 1997 2022

Research Output 1982 2017

Targeting ADAM17 inhibits human colorectal adenocarcinoma progression and tumor-initiating cell frequency

Dosch, J., Ziemke, E., Wan, S., Luker, K., Welling, T., Hardiman, K., Fearon, E., Thomas, S., Flynn, M., Rios-Doria, J., Hollingsworth, R., Herbst, R., Hurt, E. & Sebolt-Leopold, J. 2017 In : Oncotarget. 8, 39, p. 65090-65099 10 p.

Research output: Research - peer-reviewArticle

Neoplastic Stem Cells
Adenocarcinoma
Neoplasms
Therapeutics
ADAM17 Protein
2 Citations

Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor

Ramkumar, K., Samanta, S., Kyani, A., Yang, S., Tamura, S., Ziemke, E., Stuckey, J. A., Li, S., Chinnaswamy, K., Otake, H., Debnath, B., Yarovenko, V., Sebolt-Leopold, J. S., Ljungman, M. & Neamati, N. Oct 5 2016 In : Nature Communications. 7, 13084

Research output: Research - peer-reviewArticle

glutathione
inhibitors
signatures
evaluation
Glutathione Transferase
15 Citations

Sensitivity of KRAS-Mutant colorectal cancers to combination therapy that cotargets MEK and CDK4/6

Ziemke, E. K., Dosch, J. S., Maust, J. D., Shettigar, A., Sen, A., Welling, T. H., Hardiman, K. M. & Sebolt-Leopold, J. S. Jan 15 2016 In : Clinical Cancer Research. 22, 2, p. 405-414 10 p.

Research output: Research - peer-reviewArticle

Mitogen-Activated Protein Kinase Kinases
Colorectal Neoplasms
Therapeutics
Heterografts
trametinib
7 Citations

Cancer stem cell marker phenotypes are reversible and functionally homogeneous in a preclinical model of pancreatic cancer

Dosch, J. S., Ziemke, E. K., Shettigar, A., Rehemtulla, A. & Sebolt-Leopold, J. S. Nov 1 2015 In : Cancer Research. 75, 21, p. 4582-4592 11 p.

Research output: Research - peer-reviewArticle

Neoplastic Stem Cells
Pancreatic Neoplasms
Phenotype
Neoplasms
gemcitabine
12 Citations
Phosphatidylinositol 3-Kinase
Mitogen-Activated Protein Kinases
Cells
Phosphotransferases
Protein Kinase Inhibitors