Personal profile

Research interests

Dr. Diaz's research interests are in the mechanism involved in deep vein thrombosis (DVT), specifically the link between inflammation, thrombogenesis, fibrosis secondary to DVT, identification of potential therapeutic targets for DVT and models of DVT. During the past years, Dr. Diaz studied the role for interleukin 6 (IL-6) in fibrosis in DVT. These studies revealed that IL-6 may serve as a potential therapeutic target to ameliorate fibrosis associated to the post-thrombotic syndrome. Also, Dr. Diaz’s research investigates the potential benefits of statins to prevent DVT. His findings support that statins decrease inflammation (mainly through IL-6 signaling pathway) and promote fibrinolysis in the context of DVT. In addition, Dr. Diaz is investigating the role of galectins on DVT. Galectins are well-known players in cancer progression and metastasis but its role on DVT is still unknown. Patients with cancer have high risk to develop DVT and Dr. Diaz’s research direction is to explore a potential link between DVT and cancer

Education / Academic qualification

Medical Doctor, University of Buenos Aires Medical School, Buenos Aires, Argentina

… → 1992

External positions

Research Assistant Professor, Department of Surgery, Section of Vascular Surgery

2008 → …

Fingerprint Fingerprint is based on mining the text of the persons scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Inflammation Medicine & Life Sciences
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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2012 2020

Research Output 2004 2018

Deep Vein Thrombosis Exhibits Characteristic Serum and Vein Wall Metabolic Phenotypes in the Inferior Vena Cava Ligation Mouse Model

Sung, Y., Spagou, K., Kafeza, M., Kyriakides, M., Dharmarajah, B., Shalhoub, J., Diaz, J. A., Wakefield, T. W., Holmes, E. & Davies, A. H. May 1 2018 In : European Journal of Vascular and Endovascular Surgery. 55, 5, p. 703-713 11 p.

Research output: Contribution to journalArticle

Metabolomics
Venous Thromboembolism
Inferior Vena Cava
Venous Thrombosis
Ligation

Pre-Clinical Model to Study Recurrent Venous Thrombosis in the Inferior Vena Cava

Andraska, E. A., Luke, C. E., Elfline, M. A., Henke, S. P., Madapoosi, S. S., Metz, A. K., Hoinville, M. E., Wakefield, T. W., Henke, P. K. & Diaz, J. A. Apr 25 2018 (Accepted/In press) In : Thrombosis and Haemostasis.

Research output: Contribution to journalArticle

Inferior Vena Cava
Venous Thrombosis
Thrombosis
Veins
Fibrin

Statins in venous thrombosis: more evidence, more basic science findings

Palmer, O. R., Shaydakov, M. E., Rainey, J., Flaherty, M. L. & Diaz, J. A. Feb 1 2018 In : Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 66, 2, p. e3

Research output: Contribution to journalLetter

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Venous Thrombosis
4 Citations

Apixaban versus warfarin for mechanical heart valve thromboprophylaxis in a swine aortic heterotopic valve model

Lester, P. A., Coleman, D. M., Diaz, J. A., Jackson, T. O., Hawley, A. E., Mathues, A. R., Grant, B. T., Knabb, R. M., Ramacciotti, E., Frost, C. E., Song, Y., Wakefield, T. W. & Myers, D. D. May 1 2017 In : Arteriosclerosis, thrombosis, and vascular biology. 37, 5, p. 942-948 7 p.

Research output: Contribution to journalArticle

Heart Valves
Warfarin
Aortic Valve
Swine
Thoracic Aorta
Dobutamine
Inferior Vena Cava
Veins
Iliac Vein
Femoral Vein