Jolanta E Grembecka

  • 1604 Citations
  • 23 Scopus h-Index
19972021

Fingerprint Fingerprint is based on mining the text of the persons scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 5 Similar Profiles
Proteins Medicine & Life Sciences
Leukemia Medicine & Life Sciences
Leucyl Aminopeptidase Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Genes Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Catalytic Domain Medicine & Life Sciences
Plasmodium falciparum Medicine & Life Sciences

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Grants 2009 2021

Research Output 1997 2017

  • 1604 Citations
  • 23 Scopus h-Index
  • 54 Article
  • 4 Review article
  • 1 Editorial

Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin

Svoboda, L. K., Bailey, N., Van Noord, R. A., Krook, M. A., Harris, A., Cramer, C., Jasman, B., Patel, R. M., Thomas, D., Borkin, D., Cierpicki, T., Grembecka, J. & Lawlor, E. R. 2017 In : Oncotarget. 8, 1, p. 458-471 14 p.

Research output: Contribution to journalArticle

Ewing's Sarcoma
Proteins
Transcriptional Activation
Neoplasms
Leukemia

BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization

Gray, F., Cho, H. J., Shukla, S., He, S., Harris, A., Boytsov, B., Jaremko, A., Jaremko, M., Demeler, B., Lawlor, E. R., Grembecka, J. & Cierpicki, T. Nov 9 2016 In : Nature Communications. 7, 13343

Research output: Contribution to journalArticle

Polycomb Repressive Complex 1
Proteins
Oligomerization
Ubiquitin
Ubiquitination
1 Citations

H3K36 methyltransferases as cancer drug targets: Rationale and perspectives for inhibitor development

Rogawski, D. S., Grembecka, J. & Cierpicki, T. Sep 1 2016 In : Future Medicinal Chemistry. 8, 13, p. 1589-1607 19 p.

Research output: Contribution to journalReview article

Methyltransferases
Genes
Neoplasms
Alternative Splicing
Epigenomics
1 Citations

Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)

Borkin, D., Pollock, J., Kempinska, K., Purohit, T., Li, X., Wen, B., Zhao, T., Miao, H., Shukla, S., He, M., Sun, D., Cierpicki, T. & Grembecka, J. Feb 11 2016 In : Journal of Medicinal Chemistry. 59, 3, p. 892-913 22 p.

Research output: Contribution to journalArticle

Leukemia
Proteins
Lead
Myeloid-Lymphoid Leukemia Protein
Biphenotypic Acute Leukemia
5 Citations

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers

Illendula, A. , Gilmour, J. , Grembecka, J. , Tirumala, V. S. S. , Boulton, A. , Kuntimaddi, A. , Schmidt, C. , Wang, L. , Pulikkan, J. A. , Zong, H. , Parlak, M. , Kuscu, C. , Pickin, A. , Zhou, Y. , Gao, Y. , Mishra, L. , Adli, M. , Castilla, L. H. , Rajewski, R. A. , Janes, K. A. & 3 others Guzman, M. L., Bonifer, C. & Bushweller, J. H. Jun 1 2016 In : EBioMedicine. 8, p. 117-131 15 p.

Research output: Contribution to journalArticle

Transcription Factors
Neoplasms
Leukemia
Proteins
Core Binding Factors