Fingerprint Fingerprint is based on mining the text of the persons scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 8 Similar Profiles
G-Protein-Coupled Receptor Kinases Medicine & Life Sciences
G-Protein-Coupled Receptor Kinase 2 Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
Heterotrimeric GTP-Binding Proteins Medicine & Life Sciences
G-Protein-Coupled Receptors Medicine & Life Sciences
Rho Guanine Nucleotide Exchange Factors Medicine & Life Sciences
Catalytic Domain Medicine & Life Sciences
Adenylyl Cyclases Medicine & Life Sciences

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Grants 2005 2021

Research Output 1990 2018

Utilizing a structure-based docking approach to develop potent G protein-coupled receptor kinase (GRK) 2 and 5 inhibitors

Waldschmidt, H. V., Bouley, R., Kirchhoff, P. D., Lee, P., Tesmer, J. J. G. & Larsen, S. D. May 15 2018 In : Bioorganic and Medicinal Chemistry Letters. 28, 9, p. 1507-1515 9 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptor Kinases
Affinity chromatography
Phosphotransferases
Heart Failure
Amides
1 Citations

A Receptor on Acid

Chen, Q. & Tesmer, J. J. G. Jan 26 2017 In : Cell. 168, 3, p. 339-341 3 p.

Research output: Contribution to journalShort survey

Hallucinogens
Lysergic Acid Diethylamide
Aptitude
Hallucinations
Brain
2 Citations

A retractable lid in lecithin: Cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein A-I

Manthei, K. A., Ahn, J., Glukhova, A., Yuan, W., Larkin, C., Manett, T. D., Chang, L., Shayman, J. A., Axley, M. J., Schwendeman, A. & Tesmer, J. J. G. Jan 1 2017 In : Journal of Biological Chemistry. 292, 49, p. 20313-20327 15 p.

Research output: Contribution to journalArticle

Deuterium Exchange Measurement
Phosphatidylcholine-Sterol O-Acyltransferase
Lecithin
Enzyme inhibition
Lipoproteins
2 Citations

Lecithin: cholesterol acyltransferase activation by sulfhydryl-reactive small molecules: Role of cysteine-31s

Freeman, L. A., Demosky, S. J., Konaklieva, M., Kuskovsky, R., Aponte, A., Ossoli, A. F., Gordon, S. M., Koby, R. F., Manthei, K. A., Shen, M., Vaisman, B. L., Shamburek, R. D., Jadhav, A., Calabresi, L., Gucek, M., Tesmer, J. J. G., Levine, R. L. & Remaley, A. T. Aug 1 2017 In : Journal of Pharmacology and Experimental Therapeutics. 362, 2, p. 306-318 13 p.

Research output: Contribution to journalArticle

Phosphatidylcholine-Sterol O-Acyltransferase
Cysteine
Mutation
Mass Spectrometry
Lecithin Cholesterol Acyltransferase Deficiency
2 Citations

Navigating the conformational landscape of G protein–coupled receptor kinases during allosteric activation

Yao, X. Q., Cato, M. C., Labudde, E., Beyett, T. S., Tesmer, J. J. G. & Grant, B. J. 2017 In : Journal of Biological Chemistry. 292, 39, p. 16032-16043 12 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptor Kinases
Phosphotransferases
Chemical activation
G-Protein-Coupled Receptors
Phosphorylation