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  • 4 Similar Profiles
Proteins Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Catalytic Domain Medicine & Life Sciences
Substrates Chemical Compounds
Glutamine Medicine & Life Sciences
Polyketide Synthases Medicine & Life Sciences
Crystal structure Chemical Compounds
Polyketides Medicine & Life Sciences

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Grants 1997 2021

Research Output 1981 2017

Function and Structure of MalA/MalA′, Iterative Halogenases for Late-Stage C-H Functionalization of Indole Alkaloids

Fraley, A. E., Garcia-Borràs, M., Tripathi, A., Khare, D., Mercado-Marin, E. V., Tran, H., Dan, Q., Webb, G. P., Watts, K. R., Crews, P., Sarpong, R., Williams, R. M., Smith, J. L., Houk, K. N. & Sherman, D. H. Aug 30 2017 In : Journal of the American Chemical Society. 139, 34, p. 12060-12068 9 p.

Research output: Research - peer-reviewArticle

Alkaloids
Substrates
Indole Alkaloids
malbrancheamide
Halogenation

Structural and biochemical analyses indicate that a bacterial persulfide dioxygenase-rhodanese fusion protein functions in sulfur assimilation

Motl, N., Skiba, M. A., Kabil, O., Smith, J. L. & Banerjee, R. Aug 25 2017 In : Journal of Biological Chemistry. 292, 34, p. 14026-14038 13 p.

Research output: Research - peer-reviewArticle

Thiosulfate Sulfurtransferase
Dioxygenases
Sulfur
Fusion reactions
Proteins
1 Citations

Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate

Maloney, F. P., Gerwick, L., Gerwick, W. H., Sherman, D. H. & Smith, J. L. Sep 13 2016 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 37, p. 10316-10321 6 p.

Research output: Research - peer-reviewArticle

1,4-alpha-Glucan Branching Enzyme
Acyl Carrier Protein
Polyketides
Biosynthesis
Substrates
7 Citations

Can i solve my structure by SAD phasing? Anomalous signal in SAD phasing

Terwilliger, T. C., Bunkóczi, G., Hung, L. W., Zwart, P. H., Smith, J. L., Akey, D. L. & Adams, P. D. 2016 In : Acta Crystallographica Section D: Structural Biology. 72, 3, p. 346-358 13 p.

Research output: Research - peer-reviewArticle

Data Accuracy
Signal-To-Noise Ratio
Datasets
5 Citations

Can i solve my structure by SAD phasing? Planning an experiment, scaling data and evaluating the useful anomalous correlation and anomalous signal

Terwilliger, T. C., Bunkóczi, G., Hung, L. W., Zwart, P. H., Smith, J. L., Akey, D. L. & Adams, P. D. 2016 In : Acta Crystallographica Section D: Structural Biology. 72, 3, p. 359-374 16 p.

Research output: Research - peer-reviewArticle

Datasets
Signal-To-Noise Ratio
Databases