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  • 6 Similar Profiles
Proteins Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Catalytic Domain Medicine & Life Sciences
Substrates Chemical Compounds
Glutamine Medicine & Life Sciences
Polyketide Synthases Medicine & Life Sciences
Polyketides Medicine & Life Sciences
Crystal structure Chemical Compounds

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Grants 1997 2022

Research Output 1981 2017

A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit

Skiba, M. A., Sikkema, A. P., Moss, N. A., Tran, C. L., Sturgis, R. M., Gerwick, L., Gerwick, W. H., Sherman, D. H. & Smith, J. L. Dec 15 2017 In : ACS Chemical Biology. 12, 12, p. 3039-3048 10 p.

Research output: Research - peer-reviewArticle

Polyketides
Decarboxylation
Biosynthetic Pathways
Methyltransferases
Iron

APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA

Bohn, J. A., Thummar, K., York, A., Raymond, A., Brown, W. C., Bieniasz, P. D., Hatziioannou, T. & Smith, J. L. Dec 1 2017 In : Nature Communications. 8, 1, 1021

Research output: Research - peer-reviewArticle

interactions
RNA
proteins
primates
swine

Function and Structure of MalA/MalA′, Iterative Halogenases for Late-Stage C-H Functionalization of Indole Alkaloids

Fraley, A. E., Garcia-Borràs, M., Tripathi, A., Khare, D., Mercado-Marin, E. V., Tran, H., Dan, Q., Webb, G. P., Watts, K. R., Crews, P., Sarpong, R., Williams, R. M., Smith, J. L., Houk, K. N. & Sherman, D. H. Aug 30 2017 In : Journal of the American Chemical Society. 139, 34, p. 12060-12068 9 p.

Research output: Research - peer-reviewArticle

Alkaloids
Substrates
Indole Alkaloids
malbrancheamide
Halogenation

Structural and biochemical analyses indicate that a bacterial persulfide dioxygenase-rhodanese fusion protein functions in sulfur assimilation

Motl, N., Skiba, M. A., Kabil, O., Smith, J. L. & Banerjee, R. Aug 25 2017 In : Journal of Biological Chemistry. 292, 34, p. 14026-14038 13 p.

Research output: Research - peer-reviewArticle

Thiosulfate Sulfurtransferase
Dioxygenases
Sulfur
Fusion reactions
Proteins
1 Citations

Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate

Maloney, F. P., Gerwick, L., Gerwick, W. H., Sherman, D. H. & Smith, J. L. Sep 13 2016 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 37, p. 10316-10321 6 p.

Research output: Research - peer-reviewArticle

1,4-alpha-Glucan Branching Enzyme
Acyl Carrier Protein
Polyketides
Biosynthesis
Substrates