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Grants 2002 2020

Research Output 1971 2017

1 Citations

Derepression of the DNA methylation machinery of the Gata1 gene triggers the differentiation cue for erythropoiesis

Yu, L., Takai, J., Otsuki, A., Katsuoka, F., Suzuki, M., Katayama, S., Nezu, M., Engel, J. D., Moriguchi, T. & Yamamoto, M. Apr 1 2017 In : Molecular and Cellular Biology. 37, 8, e00592-16

Research output: Research - peer-reviewArticle

Erythropoiesis
DNA Methylation
Methylation
Cues
Genes

GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis

Katayama, S., Suzuki, M., Yamaoka, A., Keleku-Lukwete, N., Katsuoka, F., Otsuki, A., Kure, S., Engel, J. D. & Yamamoto, M. Aug 17 2017 In : Blood. 130, 7, p. 908-919 12 p.

Research output: Research - peer-reviewArticle

Haploinsufficiency
Genes
Leukemia
Bone
Myelodysplastic Syndromes

GATA3 abundance is a critical determinant of T cell receptor β allelic exclusion

Ku, C. J., Sekiguchi, J. A. M., Panwar, B., Guan, Y., Takahashi, S., Yoh, K., Maillard, I., Hosoya, T. & Engel, J. D. Jun 1 2017 In : Molecular and Cellular Biology. 37, 12, e00052-17

Research output: Research - peer-reviewArticle

T-Cell Antigen Receptor
Alleles
Genetic Recombination
T-Cell Receptor beta Genes
Gene Rearrangement

Intron 1 GATA site enhances ALAS2 expression indispensably during erythroid differentiation

Zhang, Y., Zhang, J., An, W., Wan, Y., Ma, S., Yin, J., Li, X., Gao, J., Yuan, W., Guo, Y., Engel, J. D., Shi, L., Cheng, T. & Zhu, X. 2017 In : Nucleic Acids Research. 45, 2, p. 657-671 15 p.

Research output: Research - peer-reviewArticle

Introns
Mutation
X-linked sideroblastic anemia
Clustered Regularly Interspaced Short Palindromic Repeats
5-Aminolevulinate Synthetase

Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study

Molokie, R. , Lavelle, D. , Gowhari, M. , Pacini, M. , Krauz, L. , Hassan, J. , Ibanez, V. , Ruiz, M. A. , Ng, K. P. , Woost, P. , Radivoyevitch, T. , Pacelli, D. , Fada, S. , Rump, M. , Hsieh, M. , Tisdale, J. F. , Jacobberger, J. , Phelps, M. , Engel, J. D. , Saraf, S. & 4 others Hsu, L. L., Gordeuk, V., DeSimone, J. & Saunthararajah, Y. Sep 1 2017 In : PLoS Medicine. 14, 9, e1002382

Research output: Research - peer-reviewArticle

decitabine
Tetrahydrouridine
Sickle Cell Anemia
Epigenomics
DNA