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ceramide glucosyltransferase Medicine & Life Sciences
Glucosylceramides Medicine & Life Sciences
Glycosphingolipids Medicine & Life Sciences
Ceramides Medicine & Life Sciences
Fabry Disease Medicine & Life Sciences
Phospholipases A2 Medicine & Life Sciences
Sphingolipids Medicine & Life Sciences
Kidney Medicine & Life Sciences

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Grants 1986 2022

Research Output 1980 2018

Targeting Glucosylceramide Synthesis in the Treatment of Rare and Common Renal Disease

Shayman, J. A. Jan 1 2018 (Accepted/In press) In : Seminars in Nephrology.

Research output: Contribution to journalArticle

Diabetic Nephropathies
Lysosomal Storage Diseases
1 Citations

A retractable lid in lecithin: Cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein A-I

Manthei, K. A., Ahn, J., Glukhova, A., Yuan, W., Larkin, C., Manett, T. D., Chang, L., Shayman, J. A., Axley, M. J., Schwendeman, A. & Tesmer, J. J. G. Jan 1 2017 In : Journal of Biological Chemistry. 292, 49, p. 20313-20327 15 p.

Research output: Contribution to journalArticle

Deuterium Exchange Measurement
Phosphatidylcholine-Sterol O-Acyltransferase
Enzyme inhibition

B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals

Leitch, A. C., Probert, P. M. E., Shayman, J. A., Meyer, S. K., Kass, G. E. N. & Wright, M. C. Jul 1 2017 In : Toxicology. 386, p. 120-132 13 p.

Research output: Contribution to journalArticle

Fatty Acids
1 Citations

Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury

Dupre, T. V., Doll, M. A., Shah, P. P., Sharp, C. N., Siow, D., Megyesi, J., Shayman, J., Bielawska, A., Bielawski, J., Beverly, L. J., Hernandez-Corbacho, M., Clarke, C. J., Snider, A. J., Schnellmann, R. G., Obeid, L. M., Hannun, Y. A. & Siskind, L. J. Jan 1 2017 In : Journal of Lipid Research. 58, 7, p. 1439-1452 14 p.

Research output: Contribution to journalArticle

ceramide glucosyltransferase
Acute Kidney Injury

Preferential hydrolysis of truncated oxidized glycerophospholipids by lysosomal phospholipase A2

Abe, A., Hiraoka, M., Ohguro, H., Tesmer, J. J. & Shayman, J. A. 2017 In : Journal of Lipid Research. 58, 2, p. 339-349 11 p.

Research output: Contribution to journalArticle

Phospholipases A2