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  • 7 Similar Profiles
Hemorrhagic Shock Medicine & Life Sciences
Resuscitation Medicine & Life Sciences
Wounds and Injuries Medicine & Life Sciences
Hemorrhage Medicine & Life Sciences
Valproic Acid Medicine & Life Sciences
Swine Medicine & Life Sciences
Hypothermia Medicine & Life Sciences
Histone Deacetylase Inhibitors Medicine & Life Sciences

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Grants 2012 2022

Research Output 1996 2018

Improvement of Blood-Brain Barrier Integrity in Traumatic Brain Injury and Hemorrhagic Shock Following Treatment with Valproic Acid and Fresh Frozen Plasma

Nikolian, V. C., Dekker, S. E., Bambakidis, T., Higgins, G. A., Dennahy, I. S., Georgoff, P. E., Williams, A. M., Andjelkovic, A. V. & Alam, H. B. Jan 1 2018 In : Critical Care Medicine. 46, 1, p. e59-e66

Research output: Contribution to journalArticle

Animal Disease Models
Hemorrhagic Shock
Vascular Endothelium
Valproic Acid
Blood-Brain Barrier

Physiologically based pharmacokinetic modeling of disposition and drug-drug interactions for valproic acid and divalproex

Conner, T. M., Nikolian, V. C., Georgoff, P. E., Pai, M. P., Alam, H. B., Sun, D., Reed, R. C. & Zhang, T. Jan 1 2018 In : European Journal of Pharmaceutical Sciences. 111, p. 465-481 17 p.

Research output: Contribution to journalArticle

Drug Design
Valproic Acid
Drug Interactions
Pharmaceutical Preparations
2 Citations

Safety and Tolerability of Intravenous Valproic Acid in Healthy Subjects: A Phase I Dose-Escalation Trial

Georgoff, P. E., Nikolian, V. C., Bonham, T., Pai, M. P., Tafatia, C., Halaweish, I., To, K., Watcharotone, K., Parameswaran, A., Luo, R., Sun, D. & Alam, H. B. Feb 1 2018 In : Clinical Pharmacokinetics. 57, 2, p. 209-219 11 p.

Research output: Contribution to journalArticle

Valproic Acid
Healthy Volunteers
Maximum Tolerated Dose

Tubastatin A prevents hemorrhage-induced endothelial barrier dysfunction

Bruhn, P. J., Nikolian, V. C., Halaweish, I., Chang, Z., Sillesen, M., Liu, B., Li, Y. & Alam, H. B. Feb 1 2018 In : Journal of Trauma and Acute Care Surgery. 84, 2, p. 386-392 7 p.

Research output: Contribution to journalArticle

Acute Lung Injury
Hemorrhagic Shock
tubastatin A
1 Citations

CitH3: A reliable blood biomarker for diagnosis and treatment of endotoxic shock

Pan, B., Alam, H. B., Chong, W., Mobley, J., Liu, B., Deng, Q., Liang, Y., Wang, Y., Chen, E., Wang, T., Tewari, M. & Li, Y. Dec 1 2017 In : Scientific Reports. 7, 1, 8972

Research output: Contribution to journalArticle

Septic Shock
Hemorrhagic Shock