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  • 7 Similar Profiles
Polyketide Synthases Medicine & Life Sciences
Streptomyces Medicine & Life Sciences
Biological Products Medicine & Life Sciences
Biosynthesis Chemical Compounds
Genes Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Polyketides Medicine & Life Sciences
Substrates Chemical Compounds

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Grants 2003 2021

Research Output 1982 2017

1 Citations

A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens

Kinnel, R. B., Esquenazi, E., Leao, T., Moss, N., Mevers, E., Pereira, A. R., Monroe, E. A., Korobeynikov, A., Murray, T. F., Sherman, D., Gerwick, L., Dorrestein, P. C. & Gerwick, W. H. May 26 2017 In : Journal of Natural Products. 80, 5, p. 1514-1521 8 p.

Research output: Research - peer-reviewArticle

Biological Products

A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst

Koch, A. A., Hansen, D. A., Shende, V. V., Furan, L. R., Houk, K. N., Jiménez-Osés, G. & Sherman, D. H. 2017 In : Journal of the American Chemical Society. 139, 38, p. 13456-13465 10 p.

Research output: Research - peer-reviewArticle

Catalytic Domain

Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization

Lowell, A. N., Demars, M. D., Slocum, S. T., Yu, F., Anand, K., Chemler, J. A., Korakavi, N., Priessnitz, J. K., Park, S. R., Koch, A. A., Schultz, P. J. & Sherman, D. H. Jun 14 2017 In : Journal of the American Chemical Society. 139, 23, p. 7913-7920 8 p.

Research output: Research - peer-reviewArticle

Polyketide Synthases
Anti-Bacterial Agents

Complete elucidation of the late steps of bafilomycin biosynthesis in Streptomyces lohii

Li, Z., Du, L., Zhang, W., Zhang, X., Jiang, Y., Liu, K., Men, P., Xu, H., Fortman, J. L., Sherman, D. H., Yu, B., Gao, S. & Li, S. Apr 28 2017 In : Journal of Biological Chemistry. 292, 17, p. 7095-7104 10 p.

Research output: Research - peer-reviewArticle

Polyketide Synthases

Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins

Almutairi, M. M., Svetlov, M. S., Hansen, D. A., Khabibullina, N. F., Klepacki, D., Kang, H. Y., Sherman, D. H., Vázquez-Laslop, N., Polikanov, Y. S. & Mankin, A. S. Sep 19 2017 In : Nucleic Acids Research. 45, 16, p. 9573-9582 10 p.

Research output: Research - peer-reviewArticle