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Molecules Chemical Compounds
Transcription Chemical Compounds
Chemical activation Chemical Compounds
Transcriptional Activation Medicine & Life Sciences
Proteins Medicine & Life Sciences
Transcription Factors Medicine & Life Sciences
Ligands Medicine & Life Sciences
Peptides Medicine & Life Sciences

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Grants 2000 2021

Research Output 1996 2018

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability

Jennings, L. E. , Schiedel, M. , Hewings, D. S. , Picaud, S. , Laurin, C. M. C. , Bruno, P. A. , Bluck, J. P. , Scorah, A. R. , See, L. , Reynolds, J. K. , Moroglu, M. , Mistry, I. N. , Hicks, A. , Guzanov, P. , Clayton, J. , Evans, C. N. G. , Stazi, G. , Biggin, P. C. , Mapp, A. K. , Hammond, E. M. & 3 others Humphreys, P. G., Filippakopoulos, P. & Conway, S. J. Jan 1 2018 (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

Intake systems
Molecular Dynamics Simulation
Fault tolerance
1 Citations

Protein cross-linking capillary electrophoresis at increased throughput for a range of protein-protein interactions

Ouimet, C. M., Dawod, M., Grinias, J., Assimon, V. A., Lodge, J., Mapp, A. K., Gestwicki, J. E. & Kennedy, R. T. Apr 21 2018 In : Analyst. 143, 8, p. 1805-1812 8 p.

Research output: Contribution to journalArticle

Capillary electrophoresis
Capillary Electrophoresis
1 Citations

X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition

Cesa, L. C., Shao, H., Srinivasan, S. R., Tse, E., Jain, C., Zuiderweg, E. R. P., Southworth, D. R., Mapp, A. K. & Gestwicki, J. E. Jan 1 2018 In : Journal of Biological Chemistry. 293, 7, p. 2370-2380 11 p.

Research output: Contribution to journalReview article

X-Linked Inhibitor of Apoptosis Protein
HSP70 Heat-Shock Proteins
3 Citations

A Bifunctional Amino Acid Enables Both Covalent Chemical Capture and Isolation of in Vivo Protein–Protein Interactions

Joiner, C. M., Breen, M. E., Clayton, J. & Mapp, A. K. Jan 17 2017 In : ChemBioChem. 18, 2, p. 181-184 4 p.

Research output: Contribution to journalArticle

Amino Acids

From fuzzy to function: The new frontier of protein-protein interactions

Pricer, R., Gestwicki, J. E. & Mapp, A. K. Jan 1 2017 In : Accounts of Chemical Research. 50, 3, p. 584-589 6 p.

Research output: Contribution to journalReview article

Chemical activation
Pharmaceutical Preparations