Fingerprint Fingerprint is based on mining the text of the persons scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 2 Similar Profiles
Neoplasms Medicine & Life Sciences
Small Cell Lung Carcinoma Medicine & Life Sciences
Proteins Medicine & Life Sciences
Proto-Oncogene Proteins c-mdm2 Medicine & Life Sciences
Clinical Trials Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Cell Line Medicine & Life Sciences
Tumor Suppressor Protein p53 Medicine & Life Sciences

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Grants 2014 2022

Research Output 2012 2018

  • 426 Citations
  • 10 h-Index
  • 10 Article
  • 2 Review article
  • 1 Chapter
  • 1 Comment/debate

Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein–Protein Interaction

Xu, S., Aguilar, A., Xu, T., Zheng, K., Huang, L., Stuckey, J., Chinnaswamy, K., Bernard, D., Fernández-Salas, E., Liu, L., Wang, M., McEachern, D., Przybranowski, S., Foster, C. & Wang, S. Feb 5 2018 In : Angewandte Chemie - International Edition. 57, 6, p. 1601-1605 5 p.

Research output: Contribution to journalArticle

Gene expression
Mass spectrometry
Genes
Crystal structure
Proteins
4 Citations

Discovery of 4-((3′R,4′S,5′R)-6-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development

Aguilar, A., Lu, J., Liu, L., Du, D., Bernard, D., McEachern, D., Przybranowski, S., Li, X., Luo, R., Wen, B., Sun, D., Wang, H., Wen, J., Wang, G., Zhai, Y., Guo, M., Yang, D. & Wang, S. Apr 13 2017 In : Journal of medicinal chemistry. 60, 7, p. 2819-2839 21 p.

Research output: Contribution to journalArticle

Carboxylic Acids
Clinical Trials, Phase I
Structure-Activity Relationship
Neoplasms
Carbon
12 Citations

Targeting the MDM2-p53 protein-protein interaction for new cancer therapy: Progress and challenges

Wang, S., Zhao, Y., Aguilar, A., Bernard, D. & Yang, C. Y. May 1 2017 In : Cold Spring Harbor Perspectives in Medicine. 7, 5, a026245

Research output: Contribution to journalReview article

Molecules
Neoplasms
Proteins
Oncology
Tumors
4 Citations

Chemical synthesis of tetracyclic terpenes and evaluation of antagonistic activity on endothelin-A receptors and voltage-gated calcium channels

Lu, J., Aguilar, A., Zou, B., Bao, W., Koldas, S., Shi, A., Desper, J., Wangemann, P., Xie, X. S. & Hua, D. H. Apr 28 2015 In : Bioorganic and Medicinal Chemistry. 23, 17, p. 5985-5998 14 p.

Research output: Contribution to journalArticle

Endothelin A Receptors
Terpenes
Calcium Channels
Electric potential
Endothelin-1
129 Citations

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for cancer treatment

Zhao, Y., Aguilar, A., Bernard, D. & Wang, S. Feb 12 2015 In : Journal of Medicinal Chemistry. 58, 3, p. 1038-1052 15 p.

Research output: Contribution to journalReview article

Clinical Trials
Neoplasms
Proteins
Therapeutics
Clinical Studies