Fingerprint Fingerprint is based on mining the text of the persons scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Neoplasms Medicine & Life Sciences
Proteins Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Cell Line Medicine & Life Sciences
Small Cell Lung Carcinoma Medicine & Life Sciences
Clinical Trials Medicine & Life Sciences
Heterografts Medicine & Life Sciences
Pyrroles Medicine & Life Sciences

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Grants 2014 2019

Research Output 2012 2015

  • 273 Citations
  • 9 Scopus h-Index
  • 8 Article
  • 1 Chapter
  • 1 Comment/debate
  • 1 Review article

Chemical synthesis of tetracyclic terpenes and evaluation of antagonistic activity on endothelin-A receptors and voltage-gated calcium channels

Lu, J., Aguilar, A., Zou, B., Bao, W., Koldas, S., Shi, A., Desper, J., Wangemann, P., Xie, X. S. & Hua, D. H. Apr 28 2015 In : Bioorganic and Medicinal Chemistry. 23, 17, p. 5985-5998 14 p.

Research output: Contribution to journalArticle

Terpenes
Calcium Channels
Endothelin-1
Vasoconstriction
Gerbillinae
75 Citations

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for cancer treatment

Zhao, Y., Aguilar, A., Bernard, D. & Wang, S. Feb 12 2015 In : Journal of Medicinal Chemistry. 58, 3, p. 1038-1052 15 p.

Research output: Contribution to journalReview article

Clinical Trials
Neoplasms
Proteins
17 Citations

BM-1197: A novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo

Bai, L., Chen, J., McEachern, D., Liu, L., Zhou, H., Aguilar, A. & Wang, S. Jun 5 2014 In : PLoS One. 9, 6, e99404

Research output: Contribution to journalArticle

Neoplasms
Small Cell Lung Carcinoma
Apoptosis
Proteins
bcl-2-Associated X Protein
9 Citations

Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannich ring-opening-cyclization reaction mechanism in spiro-oxindoles

Aguilar, A., Sun, W., Liu, L., Lu, J., McEachern, D., Bernard, D., Deschamps, J. R. & Wang, S. Dec 26 2014 In : Journal of Medicinal Chemistry. 57, 24, p. 10486-10496 11 p.

Research output: Contribution to journalArticle

Cyclization
Neoplasms
Proteins
Heterografts
50 Citations

SAR405838: An optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression

Wang, S. , Stuckey, J. A. , Meagher, J. L. , Bai, L. , Liu, L. , Lu, J. , Aguilar, A. & 15 others Sun, W., Zhao, Y., McEachern, D., Meaux, I., Barrière, C., Hoffman-Luca, C. G., Shangary, S., Yu, S., Bernard, D., Dos-Santos, O., Besret, L., Guerif, S., Pannier, P., Gorge-Bernat, D. & Debussche, L. Oct 15 2014 In : Cancer Research. 74, 20, p. 5855-5865 11 p.

Research output: Contribution to journalArticle

Neoplasms
Heterografts
Leukemia
Apoptosis
Proteins