Fingerprint Fingerprint is based on mining the text of the persons scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 1 Similar Profiles
Neoplasms Medicine & Life Sciences
Proteins Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Cell Line Medicine & Life Sciences
Small Cell Lung Carcinoma Medicine & Life Sciences
Clinical Trials Medicine & Life Sciences
Carboxylic Acids Medicine & Life Sciences
Molecules Chemical Compounds

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Grants 2014 2019

Research Output 2012 2017

  • 324 Citations
  • 9 Scopus h-Index
  • 9 Article
  • 2 Review article
  • 1 Chapter
  • 1 Comment/debate
1 Citations

Discovery of 4-((3′R,4′S,5′R)-6-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development

Aguilar, A., Lu, J., Liu, L., Du, D., Bernard, D., McEachern, D., Przybranowski, S., Li, X., Luo, R., Wen, B., Sun, D., Wang, H., Wen, J., Wang, G., Zhai, Y., Guo, M., Yang, D. & Wang, S. Apr 13 2017 In : Journal of Medicinal Chemistry. 60, 7, p. 2819-2839 21 p.

Research output: Contribution to journalArticle

Carboxylic Acids
Neoplasms
Clinical Trials, Phase I
Structure-Activity Relationship
Carbon
1 Citations

Targeting the MDM2-p53 protein-protein interaction for new cancer therapy: Progress and challenges

Wang, S., Zhao, Y., Aguilar, A., Bernard, D. & Yang, C. Y. May 1 2017 In : Cold Spring Harbor Perspectives in Medicine. 7, 5, a026245

Research output: Contribution to journalReview article

Neoplasms
Proteins
Molecules
Clinical Trials
Cecal Neoplasms
1 Citations

Chemical synthesis of tetracyclic terpenes and evaluation of antagonistic activity on endothelin-A receptors and voltage-gated calcium channels

Lu, J., Aguilar, A., Zou, B., Bao, W., Koldas, S., Shi, A., Desper, J., Wangemann, P., Xie, X. S. & Hua, D. H. Apr 28 2015 In : Bioorganic and Medicinal Chemistry. 23, 17, p. 5985-5998 14 p.

Research output: Contribution to journalArticle

Terpenes
Calcium Channels
Carbuncle
Endothelin-1
Vasoconstriction
93 Citations

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for cancer treatment

Zhao, Y., Aguilar, A., Bernard, D. & Wang, S. Feb 12 2015 In : Journal of Medicinal Chemistry. 58, 3, p. 1038-1052 15 p.

Research output: Contribution to journalReview article

Clinical Trials
Neoplasms
Proteins
22 Citations

BM-1197: A novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo

Bai, L., Chen, J., McEachern, D., Liu, L., Zhou, H., Aguilar, A. & Wang, S. Jun 5 2014 In : PLoS One. 9, 6, e99404

Research output: Contribution to journalArticle

remission
lung neoplasms
apoptosis
neoplasms
mice