Life Sciences Institute

Research Output 1969 2017

2017

A Bifunctional Amino Acid Enables Both Covalent Chemical Capture and Isolation of in Vivo Protein–Protein Interactions

Joiner, C. M., Breen, M. E., Clayton, J. & Mapp, A. K. Jan 17 2017 In : ChemBioChem. 18, 2, p. 181-184 4 p.

Research output: Contribution to journalArticle

Amino Acids
Proteins
Alkynes
Azides
Biotin

A few words of introduction from your new diabetes editorial board

Myers, M. G., D'Alessio, D. A., Gannon, M. A., Seeley, R. J., Burant, C. F., Doria, A., Grant, M. B., Herman, W. H., Herold, K. C., Horowitz, J. F., Lin, J. D., Lumeng, C. N. K., MacDougald, O. A., Pietropaolo, M., Pop-Busui, R., Satin, L., Stoffers, D. A. & White, M. F. Jan 1 2017 In : Diabetes. 66, 1, p. 3-4 2 p.

Research output: Contribution to journalComment/debate

1 Citations

An Hdac1/Rpd3-Poised Circuit Balances Continual Self-Renewal and Rapid Restriction of Developmental Potential during Asymmetric Stem Cell Division

Janssens, D. H., Hamm, D. C., Anhezini, L., Xiao, Q., Siller, K. H., Siegrist, S. E., Harrison, M. M. & Lee, C. Y. Feb 27 2017 In : Developmental Cell. 40, 4, p. 367-380.e7

Research output: Contribution to journalArticle

Ear Protective Devices
Asymmetric Cell Division
Histones
Stem Cells
Histone Deacetylases
1 Citations

An intramolecular interaction within the lipid kinase Fab1 regulates cellular phosphatidylinositol 3,5-bisphosphate lipid levels

Lang, M. J., Strunk, B. S., Azad, N., Petersen, J. L. & Weisman, L. S. Apr 1 2017 In : Molecular Biology of the Cell. 28, 7, p. 858-864 7 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Cysteine
Phosphotransferases
Lipids
Mutation

A pathway of targeted autophagy is induced by DNA damage in budding yeast

Eapen, V. V., Waterman, D. P., Bernard, A., Schiffmann, N., Sayas, E., Kamber, R., Lemos, B., Memisoglu, G., Ang, J., Mazella, A., Chuartzman, S. G., Loewith, R. J., Schuldiner, M., Denic, V., Klionsky, D. J. & Haber, J. E. Feb 14 2017 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. E1158-E1167

Research output: Contribution to journalArticle

Saccharomycetales
Autophagy
DNA Damage
Mutagens
Proteins
1 Citations

A Receptor on Acid

Chen, Q. & Tesmer, J. J. G. Jan 26 2017 In : Cell. 168, 3, p. 339-341 3 p.

Research output: Contribution to journalShort survey

Hallucinogens
Lysergic Acid Diethylamide
Hallucinations
Serotonin
Acids

Autophagic membrane delivery through ATG9

Feng, Y. & Klionsky, D. J. Jan 10 2017 In : Cell Research.

Research output: Contribution to journalArticle

Autophagy
Membranes
trans-Golgi Network
Starvation
Phosphotransferases
3 Citations
Autophagy
Medicine
Nobel Prize
Explosions
Secretory Pathway

BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins

Rauch, J. N., Tse, E., Freilich, R., Mok, S. A., Makley, L. N., Southworth, D. R. & Gestwicki, J. E. Jan 6 2017 In : Journal of Molecular Biology. 429, 1, p. 128-141 14 p.

Research output: Contribution to journalArticle

HSP70 Heat-Shock Proteins
Proteins
Crystallins
Adenosine Triphosphate
Protein Unfolding

Blame it on Southern, but it's a western blot

Klionsky, D. J. Jan 2 2017 In : Autophagy. 13, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Southern Blotting
Western Blotting
Molecular Biology
Genome
Polymerase Chain Reaction

Comparative analysis of satellite DNA in the drosophila melanogaster species complex

Jagannathan, M., Warsinger-Pepe, N., Watase, G. J. & Yamashita, Y. M. 2017 In : G3: Genes, Genomes, Genetics. 7, 2, p. 693-704 12 p.

Research output: Contribution to journalArticle

Satellite DNA
Drosophila melanogaster
Genome
Genetic Techniques
Heterochromatin

Conformationally Preorganized Diastereomeric Norbornane-Based Maltosides for Membrane Protein Study: Implications of Detergent Kink for Micellar Properties

Das, M., Du, Y., Ribeiro, O., Hariharan, P., Mortensen, J. S., Patra, D., Skiniotis, G., Loland, C. J., Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S. Mar 1 2017 In : Journal of the American Chemical Society. 139, 8, p. 3072-3081 10 p.

Research output: Contribution to journalArticle

Norbornanes
Membrane Proteins
Proteins
Detergents
Membranes

Conserved function of the long noncoding RNA Blnc1 in brown adipocyte differentiation

Mi, L., Zhao, X. Y., Li, S., Yang, G. & Lin, J. D. Jan 1 2017 In : Molecular Metabolism. 6, 1, p. 101-110 10 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Ribonucleoproteins
RNA
Gene Expression
Genes
1 Citations

Cutting edge: Notch signaling promotes the plasticity of group-2 innate lymphoid cells

Zhang, K., Xu, X., Pasha, M. A., Siebel, C. W., Costello, A., Haczku, A., MacNamara, K., Liang, T., Zhu, J., Bhandoola, A., Maillard, I. & Yang, Q. Mar 1 2017 In : Journal of Immunology. 198, 5, p. 1798-1803 6 p.

Research output: Contribution to journalArticle

Lymphocytes
Cytokines
Interleukin-17
Pyroglyphidae
Interleukin-13

Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids

Li, S., Lowell, A. N., Newmister, S. A., Yu, F., Williams, R. M. & Sherman, D. H. May 1 2017 In : Nature Chemical Biology. 13, 5, p. 467-469 3 p.

Research output: Contribution to journalArticle

Cyanobacteria
Cyclization
Alkaloids

Direct quantification of autophagic flux by a single molecule-based probe

Geng, J. & Klionsky, D. J. Apr 3 2017 In : Autophagy. 13, 4, p. 639-641 3 p.

Research output: Contribution to journalEditorial

Autophagy
Drug Discovery
Fluorescence
1 Citations

Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis

Cahill, T. J. , Thomsen, A. R. B. , Tarrasch, J. T. , Plouffe, B. , Nguyen, A. H. , Yang, F. , Huang, L. Y. , Kahsai, A. W. , Bassoni, D. L. , Gavino, B. J. , Lamerdin, J. E. , Triest, S. , Shukla, A. K. , Berger, B. , Little, J. , Antar, A. , Blanc, A. , Qu, C. X. , Chen, X. , Kawakami, K. & 7 others Inoue, A., Aoki, J., Steyaert, J., Sun, J. P., Bouvier, M., Skiniotis, G. & Lefkowitz, R. J. Mar 7 2017 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 10, p. 2562-2567 6 p.

Research output: Contribution to journalArticle

Arrestin
G-Protein-Coupled Receptors
Endocytosis
Arrestins
GTP-Binding Proteins

Does relevancy matter?

Klionsky, D. J. 2017 In : Biochemistry and Molecular Biology Education.

Research output: Contribution to journalArticle

Environmental pseudomonads inhibit cystic fibrosis patient-derived Pseudomonas aeruginosa

Chatterjee, P., Davis, E., Yu, F., James, S., Wildschutte, J. H., Wiegmann, D. D., Sherman, D. H., McKay, R. M., LiPuma, J. J. & Wildschutte, H. 2017 In : Applied and Environmental Microbiology. 83, 2, e02701-16

Research output: Contribution to journalArticle

antibiotics
habitat
Cystic Fibrosis
Pseudomonas aeruginosa
soil ecosystem

Evaluating the mTOR Pathway in Physiological and Pharmacological Settings

Hong, S. & Inoki, K. 2017 Methods in Enzymology. Academic Press Inc., Vol. 587, p. 405-428 24 p. (Methods in Enzymology; vol. 587)

Research output: Chapter in Book/Report/Conference proceedingChapter

Sirolimus
Pharmacology
Intercellular Signaling Peptides and Proteins
Cell Proliferation
Food

Evaluation of the asymmetric division of Drosophila male germline stem cells

Inaba, M. & Yamashita, Y. M. 2017 Methods in Molecular Biology. Humana Press Inc., Vol. 1463, p. 49-62 14 p. (Methods in Molecular Biology; vol. 1463)

Research output: Chapter in Book/Report/Conference proceedingChapter

Asymmetric Cell Division
Drosophila
Stem Cells
Homeostasis

Fetal hematopoietic stem cells are making waves

Waas, B. & Maillard, I. Apr 1 2017 In : Stem Cell Investigation. 4, 4

Research output: Contribution to journalEditorial

Fetal Stem Cells
Hematopoietic Stem Cells
2 Citations

Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma

Wang, Y. , Huang, D. , Chen, K. Y. , Cui, M. , Wang, W. , Huang, X. , Awadellah, A. , Li, Q. , Friedman, A. , Xin, W. W. , Di Martino, L. , Cominelli, F. , Miron, A. , Chan, R. , Fox, J. G. , Xu, Y. , Shen, X. , Kalady, M. F. , Markowitz, S. , Maillard, I. & 3 others Lowe, J. B., Xin, W. & Zhou, L. Jan 1 2017 In : Gastroenterology. 152, 1, p. 193-205.e10

Research output: Contribution to journalArticle

Colitis
Adenocarcinoma
Colorectal Neoplasms
Colon
Guanosine Diphosphate Fucose

Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis

van Rooij, F. J. A. , Qayyum, R. , Smith, A. V. , Zhou, Y. , Trompet, S. , Tanaka, T. , Keller, M. F. , Chang, L. C. , Schmidt, H. , Yang, M. L. , Chen, M. H. , Hayes, J. , Johnson, A. D. , Yanek, L. R. , Mueller, C. , Lange, L. , Floyd, J. S. , Ghanbari, M. , Zonderman, A. B. , Jukema, J. W. & 80 others Hofman, A., van Duijn, C. M., Desch, K. C., Saba, Y., Ozel, A. B., Snively, B. M., Wu, J. Y., Schmidt, R., Fornage, M., Klein, R. J., Fox, C. S., Matsuda, K., Kamatani, N., Wild, P. S., Stott, D. J., Ford, I., Slagboom, P. E., Yang, J., Chu, A. Y., Lambert, A. J., Uitterlinden, A. G., Franco, O. H., Hofer, E., Ginsburg, D., Hu, B., Keating, B., Schick, U. M., Brody, J. A., Li, J. Z., Chen, Z., Zeller, T., Guralnik, J. M., Chasman, D. I., Peters, L. L., Kubo, M., Becker, D. M., Li, J., Eiriksdottir, G., Rotter, J. I., Levy, D., Grossmann, V., Patel, K. V., Chen, C. H., Ridker, P. M., Tang, H., Launer, L. J., Rice, K. M., Li-Gao, R., Ferrucci, L., Evans, M. K., Choudhuri, A., Trompouki, E., Abraham, B. J., Yang, S., Takahashi, A., Kamatani, Y., Kooperberg, C., Harris, T. B., Jee, S. H., Coresh, J., Tsai, F. J., Longo, D. L., Chen, Y. T., Felix, J. F., Yang, Q., Psaty, B. M., Boerwinkle, E., Becker, L. C., Mook-Kanamori, D. O., Wilson, J. G., Gudnason, V., O'Donnell, C. J., Dehghan, A., Cupples, L. A., Nalls, M. A., Morris, A. P., Okada, Y., Reiner, A. P., Zon, L. I. & Ganesh, S. K. Jan 5 2017 In : American Journal of Human Genetics. 100, 1, p. 51-63 13 p.

Research output: Contribution to journalArticle

Genetic Loci
Erythropoiesis
Genome-Wide Association Study
Meta-Analysis
Erythrocytes

Glucose Sensing by Skeletal Myocytes Couples Nutrient Signaling to Systemic Homeostasis

Meng, Z. X., Gong, J., Chen, Z., Sun, J., Xiao, Y., Wang, L., Li, Y., Liu, J., Xu, X. Z. S. & Lin, J. D. May 4 2017 In : Molecular Cell. 66, 3, p. 332-344.e4

Research output: Contribution to journalArticle

Skeletal Muscle Fibers
Homeostasis
Glucose
Food
Insulin
1 Citations

GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors

Chiu, S. L., Diering, G. H., Ye, B., Takamiya, K., Chen, C. M., Jiang, Y., Niranjan, T., Schwartz, C. E., Wang, T. & Huganir, R. L. Mar 22 2017 In : Neuron. 93, 6, p. 1405-1419.e8

Research output: Contribution to journalArticle

Neuronal Plasticity
AMPA Receptors
Learning
Endosomes
Intellectual Disability

High-resolution crystal structures of Colocasia esculenta tarin lectin

Pereira, P. R., Meagher, J. L., Winter, H. C., Goldstein, I. J., Paschoalin, V. M. F., Silva, J. T. & Stuckey, J. A. 2017 In : Glycobiology. 27, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

Colocasia
Lectins
Galanthus
Agglutinins
Mannose

HS1BP3 provides a novel mechanism of negative autophagy regulation through membrane lipids

Yin, Z. & Klionsky, D. J. Apr 14 2017 In : Autophagy. p. 1-2 2 p.

Research output: Contribution to journalArticle

Autophagy
Membrane Lipids
Lipids
Phosphatidic Acids
Transferrin Receptors
3 Citations

Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering

Koryakina, I., Kasey, C., McArthur, J. B., Lowell, A. N., Chemler, J. A., Li, S., Hansen, D. A., Sherman, D. H. & Williams, G. J. Jan 20 2017 In : ACS chemical biology. 12, 1, p. 114-123 10 p.

Research output: Contribution to journalArticle

Polyketide Synthases
Acyltransferases
Polyketides
Amino Acid Substitution
Substrate Specificity

Isolation of mouse stromal vascular cells for monolayer culture

Liu, L., Zheng, L. D., Donnelly, S. R., Emont, M. P., Wu, J. & Cheng, Z. 2017 Methods in Molecular Biology. Humana Press Inc., Vol. 1566, p. 9-16 8 p. (Methods in Molecular Biology; vol. 1566)

Research output: Chapter in Book/Report/Conference proceedingChapter

Stromal Cells
Blood Vessels
Cell Culture Techniques
Adipogenesis
Tissue Expansion

Notch ligand delta-like 4 promotes regulatory T cell identity in pulmonary viral infection

Ting, H. A., Schaller, M. A., Nagata, D. E. D. A., Rasky, A. J., Maillard, I. P. & Lukacs, N. W. Feb 15 2017 In : Journal of Immunology. 198, 4, p. 1492-1502 11 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Ligands
Lung
Infection
Respiratory Syncytial Virus Infections

Novel hypophysiotropic AgRP2 neurons and pineal cells revealed by BAC transgenesis in zebrafish

Shainer, I., Buchshtab, A., Hawkins, T. A., Wilson, S. W., Cone, R. D. & Gothilf, Y. Mar 20 2017 In : Scientific Reports. 7, 44777

Research output: Contribution to journalArticle

Gene Transfer Techniques
Zebrafish
Neurons
Hypothalamus
Agouti-Related Protein

PHB2/prohibitin 2: An inner membrane mitophagy receptor

Lahiri, V. & Klionsky, D. J. Mar 1 2017 In : Cell Research. 27, 3, p. 311-312 2 p.

Research output: Contribution to journalReview article

Mitochondria
Mitochondrial Degradation

PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis

Parvanov, E. D., Tian, H., Billings, T., Saxl, R. L., Spruce, C., Aithal, R., Krejci, L., Paigen, K., Petkov, P. M. & Yamashita, Y. Feb 1 2017 In : Molecular Biology of the Cell. 28, 3, p. 488-499 12 p.

Research output: Contribution to journalArticle

Meiosis
Genetic Recombination
Proteins
Spermatocytes
DNA

Preferential hydrolysis of truncated oxidized glycerophospholipids by lysosomal phospholipase A2

Abe, A., Hiraoka, M., Ohguro, H., Tesmer, J. J. & Shayman, J. A. 2017 In : Journal of Lipid Research. 58, 2, p. 339-349 11 p.

Research output: Contribution to journalArticle

Glycerophospholipids
Phospholipases A2
Hydrolysis
Phosphorylcholine
Phosphatidylcholines

Safety and immunogenicity of mammalian cell derived and Modified Vaccinia Ankara vectored African swine fever subunit antigens in swine

Lopera-Madrid, J., Osorio, J. E., He, Y., Xiang, Z., Adams, L. G., Laughlin, R. C., Mwangi, W., Subramanya, S., Neilan, J., Brake, D., Burrage, T. G., Brown, W. C., Clavijo, A. & Bounpheng, M. A. Mar 1 2017 In : Veterinary Immunology and Immunopathology. 185, p. 20-33 14 p.

Research output: Contribution to journalArticle

African Swine Fever
Vaccinia
Swine
Safety
Antigens
Gastropoda
Snails
Mesenchymal Stromal Cells
Osteogenesis
Epithelial-Mesenchymal Transition

spict, a cyst cell-specific gene, regulates starvation-induced spermatogonial cell death in the Drosophila testis

Chiang, A. C. Y., Yang, H. & Yamashita, Y. M. Jan 10 2017 In : Scientific Reports. 7, 40245

Research output: Contribution to journalArticle

Starvation
Drosophila
Testis
Cysts
Cell Death

Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine

Waldschmidt, H. V., Homan, K. T., Cato, M. C., Cruz-Rodríguez, O., Cannavo, A., Wilson, M. W., Song, J., Cheung, J. Y., Koch, W. J., Tesmer, J. J. G. & Larsen, S. D. Apr 13 2017 In : Journal of Medicinal Chemistry. 60, 7, p. 3052-3069 18 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptor Kinase 2
Paroxetine
G-Protein-Coupled Receptor Kinases
Heterotrimeric GTP-Binding Proteins
Drug Design

The molecular mechanism of Atg13 function in autophagy induction: What is hidden behind the data?

Popelka, H. & Klionsky, D. J. Mar 4 2017 In : Autophagy. p. 1-3 3 p.

Research output: Contribution to journalArticle

Autophagy
Yeasts
Proteins
Class III Phosphatidylinositol 3-Kinases
Crystallography
2 Citations

The Vps13p-Cdc31p complex is directly required for TGN late endosome transport and TGN homotypic fusion

De, M., Oleskie, A. N., Ayyash, M., Dutta, S., Mancour, L., Abazeed, M. E., Brace, E. J., Skiniotis, G. & Fuller, R. S. 2017 In : Journal of Cell Biology. 216, 2, p. 425-439 15 p.

Research output: Contribution to journalArticle

trans-Golgi Network
Endosomes
Yeasts
Genes
Phosphatidic Acids

Xenophagy: A battlefield between host and microbe, and a possible avenue for cancer treatment

Mao, K. & Klionsky, D. J. Feb 1 2017 In : Autophagy. 13, 2, p. 223-224 2 p.

Research output: Contribution to journalEditorial

Autophagy
Eukaryota
Neoplasms
Mitochondrial Degradation
Antiviral Agents
2016
9 Citations

2.8-Å Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania

Shalev-Benami, M., Zhang, Y., Matzov, D., Halfon, Y., Zackay, A., Rozenberg, H., Zimmerman, E., Bashan, A., Jaffe, C. L., Yonath, A. & Skiniotis, G. Mar 13 2016 In : Cell Reports.

Research output: Contribution to journalArticle

Eukaryotic Large Ribosome Subunits
Large Ribosome Subunits
Leishmania
Parasites
Leishmania donovani

Aberrant mTORC1 activation kills tubular cells by inactivating miR148b-3p

Inoki, K. Dec 1 2016 In : Kidney International. 90, 6, p. 1146-1148 3 p.

Research output: Contribution to journalComment/debate

Sirolimus
Cell Death
Kidney
Endoplasmic Reticulum Stress
Tumor Necrosis Factor-alpha
1 Citations

A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification

Chaudhuri, J., Bose, N., Gong, J., Hall, D., Rifkind, A., Bhaumik, D., Peiris, T. H., Chamoli, M., Le, C. H., Liu, J., Lithgow, G. J., Ramanathan, A., Xu, X. Z. S. & Kapahi, P. Nov 21 2016 In : Current Biology. 26, 22, p. 3014-3025 12 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Pathology
Neurodegenerative Diseases
Phosphotransferases
Calcium
1 Citations

A Crystallographic Examination of Predisposition versus Preorganization in de Novo Designed Metalloproteins

Ruckthong, L., Zastrow, M. L., Stuckey, J. A. & Pecoraro, V. L. Sep 14 2016 In : Journal of the American Chemical Society. 138, 36, p. 11979-11988 10 p.

Research output: Contribution to journalArticle

Metalloproteins
Metals
Proteins
Cysteine
Retroelements
1 Citations

Adipose Snail1 Regulates Lipolysis and Lipid Partitioning by Suppressing Adipose Triacylglycerol Lipase Expression

Sun, C., Jiang, L., Liu, Y., Shen, H., Weiss, S. J., Zhou, Y. & Rui, L. Nov 15 2016 In : Cell Reports. 17, 8, p. 2015-2027 13 p.

Research output: Contribution to journalArticle

Lipolysis
Lipase
Lipids
Adipocytes
Fats

Alternative autophagy, brefeldin A and viral trafficking pathways

Grose, C. & Klionsky, D. J. Aug 11 2016 In : Autophagy. p. 1-2 2 p.

Research output: Contribution to journalArticle

Brefeldin A
Autophagy
Membranes
DNA Viruses
RNA Viruses
9 Citations

A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster

Patel, M. R., Miriyala, G. K., Littleton, A. J., Yang, H., Trinh, K., Young, J. M., Kennedy, S. R., Yamashita, Y. M., Pallanck, L. J. & Malik, H. S. Aug 2 2016 In : eLife. 5, AUGUST, e16923

Research output: Contribution to journalArticle

Electron Transport Complex IV
Drosophila melanogaster
Mitochondrial DNA
Fertility
Mutation
1 Citations

Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate

Maloney, F. P., Gerwick, L., Gerwick, W. H., Sherman, D. H. & Smith, J. L. Sep 13 2016 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 37, p. 10316-10321 6 p.

Research output: Contribution to journalArticle

1,4-alpha-Glucan Branching Enzyme
Acyl Carrier Protein
Polyketides
Anatomy
Coenzyme A