Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors
Caitlin M O’Connor, Daniel Leonard, Danica Wiredja, Rita A Avelar, Zhizhi Wang, Daniela Schlatzer, Benjamin Bryson, Eesha Tokala, Sarah E Taylor, Aditya Upadhyay, Jaya Sangodkar, Anne-Claude Gingras, Jukka Westermarck, Wenqing Xu, Analisa DiFeo, David L Brautigan, Shozeb Haider, Mark Jackson, Goutham Narla
The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells
Erika Parasido, George S Avetian, Aisha Naeem, Garrett Graham, Michael Pishvaian, Eric Glasgow, Shaila Mudambi, Yichien Lee, Chukwuemeka Ihemelandu, Muhammad Choudhry, Ivana Peran, Partha P Banerjee, Maria Laura Avantaggiati, Kirsten Bryant, Elisa Baldelli, Mariaelena Pierobon, Lance Liotta, Emanuel Petricoin, Stanley T Fricke, Aimy Sebastian, Joseph Cozzitorto, Gabriela G Loots, Deepak Kumar, Stephen Byers, Eric Londin, Analisa DiFeo, Goutham Narla, Jordan Winter, Jonathan R Brody, Olga Rodriguez, Chris Albanese
Small molecule activators of protein phosphatase 2A for the treatment of castration-resistant prostate cancer.
Kimberly McClinch, Rita A Avelar, David Callejas, Sudeh Izadmehr, Danica Wiredja, Abbey Perl, Jaya Sangodkar, David B Kastrinsky, Daniela Schlatzer, Maxwell Cooper, Janna Kiselar, Agnes Stachnik, Shen Yao, Divya Hoon, Daniel McQuaid, Nilesh Zaware, Yixuan Gong, David L Brautigan, Stephen R Plymate, Cynthia CT Sprenger, William K Oh, Alice C Levine, Alexander Kirschenbaum, John P Sfakianos, Rosalie Sears, Analisa DiFeo, Yiannis Ioannou, Michael Ohlmeyer, Goutham Narla, Matthew D Galsky
Positively selected enhancer elements endow osteosarcoma cells with metastatic competence
James J Morrow, Ian Bayles, Alister PW Funnell, Tyler E Miller, Alina Saiakhova, Michael M Lizardo, Cynthia F Bartels, Maaike Y Kapteijn, Stevephen Hung, Arnulfo Mendoza, Gursimran Dhillon, Daniel R Chee, Jay T Myers, Frederick Allen, Marco Gambarotti, Alberto Righi, Analisa DiFeo, Brian P Rubin, Alex Y Huang, Paul S Meltzer, Lee J Helman, Piero Picci, Henri H Versteeg, John A Stamatoyannopoulos, Chand Khanna, Peter C Scacheri
CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors
Caner Saygin, Andrew Wiechert, Vinay S Rao, Ravi Alluri, Elizabeth Connor, Praveena S Thiagarajan, James S Hale, Yan Li, Anastasia Chumakova, Awad Jarrar, Yvonne Parker, Daniel J Lindner, Anil Belur Nagaraj, J Julie Kim, Analisa DiFeo, Fadi W Abdul-Karim, Chad Michener, Peter G Rose, Robert DeBernardo, Haider Mahdi, Keith R McCrae, Feng Lin, Justin D Lathia, Ofer Reizes
Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth
Jaya Sangodkar, Abbey Perl, Rita Tohme, Janna Kiselar, David B Kastrinsky, Nilesh Zaware, Sudeh Izadmehr, Sahar Mazhar, Danica D Wiredja, Caitlin M O’Connor, Divya Hoon, Neil S Dhawan, Daniela Schlatzer, Shen Yao, Daniel Leonard, Alain C Borczuk, Giridharan Gokulrangan, Lifu Wang, Elena Svenson, Caroline C Farrington, Eric Yuan, Rita A Avelar, Agnes Stachnik, Blake Smith, Vickram Gidwani, Heather M Giannini, Daniel McQuaid, Kimberly McClinch, Zhizhi Wang, Alice C Levine, Rosalie C Sears, Edward Y Chen, Qiaonan Duan, Manish Datt, Shozeb Haider, Avi Ma’ayan, Analisa DiFeo, Neelesh Sharma, Matthew D Galsky, David L Brautigan, Yiannis A Ioannou, Wenqing Xu, Mark R Chance, Michael Ohlmeyer, Goutham Narla
Cisplatin induces stemness in ovarian cancer
Andrew Wiechert, Caner Saygin, Praveena S Thiagarajan, Vinay S Rao, James S Hale, Nikhil Gupta, Masahiro Hitomi, Anil Belur Nagaraj, Analisa DiFeo, Justin D Lathia, Ofer Reizes
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