Blockade of cell volume regulatory protein NKCC1 increases TMZ-induced glioma apoptosis and reduces astrogliosis

Lanxin Luo, Xiudong Guan, Gulnaz Begum, Dawei Ding, Jenesis Gayden, Nabiul Hasan, Victoria M Fiesler, Jacob Dodelson, Gary Kohanbash, Baoli Hu, Nduka M Amankulor, Wang Jia, Maria Castro, Baoshan Sun, Dandan Sun

2020, Molecular Cancer Therapeutics - Article

Functional assay to assess T-cell inhibitory properties of myeloid derived suppressor cells (MDSCs) isolated from the tumor microenvironment of murine glioma models

Mahmoud S Alghamri, Neha Kamran, Padma Kadiyala, Pedro Lowenstein, Maria Castro

2020, Tumor Immunology and Immunotherapy – Cellular Methods Part B - Chapter

Isolation and characterization of immune cells from the tumor microenvironment of genetically engineered pediatric high-grade glioma models using the sleeping beauty transposon system

Maria Belen Garcia-Fabiani, Andrea Comba, Padma Kadiyala, Santiago Haase, Felipe Javier Núñez, David Altshuler, Pedro Lowenstein, Maria Castro

2020, Tumor Immunology and Immunotherapy – Cellular Methods Part B - Chapter

Functional characterization of tumor antigen-specific T-cells isolated from the tumor microenvironment of sleeping beauty induced murine glioma models

Mahmoud S Alghamri, Felipe J Núñez, Neha Kamran, Stephen Carney, David Altshuler, Pedro Lowenstein, Maria Castro

2020, Tumor Immunology and Immunotherapy – Cellular Methods Part A - Chapter

Epigenetic reprogramming and chromatin accessibility in pediatric diffuse intrinsic pontine gliomas: a neural developmental disease.

Flor M Mendez, Felipe J Núñez, Maria B Garcia-Fabiani, Santiago Haase, Stephen Carney, Jessica C Gauss, Oren J Becher, Pedro Lowenstein, Maria Castro

2019, Neuro-Oncology - Article

Effect of caveolin-1 on Stat3-ptyr705 levels in breast and lung carcinoma cells

Mulu Geletu, Zaid Taha, Rozanne Arulanandam, Reva Mohan, Hikmat H Assi, Maria Castro, Ivan Robert Nabi, Patrick T Gunning, Leda Raptis

2019, Biochemistry and Cell Biology - Article

Engineering patient-specific cancer immunotherapies

Lindsay Scheetz, Kyung Soo Park, Qiao Li, Pedro Lowenstein, Maria Castro, Anna Schwendeman, James Moon

2019, Nature Biomedical Engineering - Article

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

Felipe J Núñez, Flor M Mendez, Padma Kadiyala, Mahmoud S Alghamri, Masha G Savelieff, Maria B Garcia-Fabiani, Santiago Haase, Carl Koschmann, Anda-Alexandra Calinescu, Neha Kamran, Meghna Saxena, Rohin Patel, Stephen Carney, Marissa Z Guo, Marta Edwards, Mats Ljungman, Tingting Qin, Maureen Sartor, Rebecca Tagett, Sriram Venneti, Jacqueline Brosnan-Cashman, Alan Meeker, Vera Gorbunova, Lili Zhao, Daniel M Kremer, Li Zhang, Costas Lyssiotis, Lindsey Jones, Cameron J Herting, James L Ross, Dolores Hambardzumyan, Shawn Hervey-Jumper, Maria E Figueroa, Pedro Lowenstein, Maria Castro

2019, Science Translational Medicine - Article

High-Density Lipoprotein-Mimicking Nanodiscs for Chemo-immunotherapy against Glioblastoma Multiforme.

Padma Kadiyala, Dan Li, Fernando M Nuñez, David Altshuler, Robert Doherty, Rui Kuai, Minzhi Yu, Neha Kamran, Marta Edwards, James Moon, Pedro Lowenstein, Maria Castro, Anna Schwendeman

2019, ACS Nano - Article

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures.

Felipe J Núñez, Flor M Mendez, Maria B Garcia-Fabiani, Joaquín Pardo, Marta Edwards, Pedro Lowenstein, Maria Castro

2019, Journal of Visualized Experiments - Article

A platform for artificial intelligence based identification of the extravasation potential of cancer cells into the brain metastatic niche

C Ryan Oliver, Megan A Altemus, Trisha M Westerhof, Hannah Cheriyan, Xu Cheng, Michelle Dziubinski, Zhifen Wu, Joel Yates, Aki Morikawa, Jason Heth, Maria Castro, Brendan M Leung, Shuichi Takayama, Sofia Merajver

2019, Lab on a Chip - Article

Molecular ablation of tumor blood vessels inhibits therapeutic effects of radiation and bevacizumab.

Vivekanand Yadav, David Altshuler, Padma Kadiyala, Daniel Zamler, Andrea Comba, Henry Appelman, Patrick Dunn, Carl Koschmann, Maria Castro, Pedro R Löwenstein, Pedro Lowenstein

2018, Neuro-Oncology - Article

Immature myeloid cells in the tumor microenvironment: Implications for immunotherapy

Neha Kamran, Mayuri Chandran, Pedro Lowenstein, Maria Castro

2018, Clinical Immunology - Article

Evolutionary basis of a new gene- and immune-therapeutic approach for the treatment of malignant brain tumors: from mice to clinical trials for glioma patients

Pedro Lowenstein, Maria Castro

2018, Clinical Immunology - Article

Melanoma induced immunosuppression is mediated by hematopoietic dysregulation

Neha Kamran, Youping Li, Maria Sierra, Mahmoud S Algahmri, Padma Kadiyala, Henry Appelman, Marta Edwards, Pedro Lowenstein, Maria Castro

2018, OncoImmunology - Article

Native Chromatin Immunoprecipitation Using Murine Brain Tumor Neurospheres.

Flor M Mendez, Felipe J Núñez, Rocío I Zorrilla-Veloz, Pedro Lowenstein, Maria Castro

2018, Journal of Visualized Experiments - Article

Dual activation of Toll-like receptors 7 and 9 impairs the efficacy of antitumor vaccines in murine models of metastatic breast cancer

Mariela A Moreno Ayala, María Florencia Gottardo, María Soledad Gori, Alejandro Javier Nicola Candia, Carla Caruso, Andrea De Laurentiis, Mercedes Imsen, Slobodanka Klein, Elisa Bal de Kier Joffé, Gabriela Salamone, Maria Castro, Adriana Seilicovich, Marianela Candolfi

2017, Journal of Cancer Research and Clinical Oncology - Article

Single vs. combination immunotherapeutic strategies for glioma.

Mayuri Chandran, Marianela Candolfi, Diana Shah, Yohei Mineharu, Vivekanand Yadav, Carl Koschmann, Antonela S Asad, Pedro Lowenstein, Maria Castro

2017, Expert Opinion on Biological Therapy - Article

Matrix Metalloproteinase Activity in Infections by an Encephalitic Virus, Mouse Adenovirus Type 1

Shanna L Ashley, Carla D Pretto, Matthew T Stier, Padma Kadiyala, Luiza Castro-Jorge, Tien-Huei Hsu, Robert Doherty, Kelly E Carnahan, Maria Castro, Pedro Lowenstein, Katherine Spindler

2017, Journal of Virology - Article

Survival and Proliferation of Neural Progenitor–Derived Glioblastomas Under Hypoxic Stress is Controlled by a CXCL12/CXCR4 Autocrine-Positive Feedback Mechanism

Anda-Alexandra Calinescu, Vivekanand Yadav, Erica Carballo, Padma Kadiyala, Dustin Tran, Daniel B Zamler, Robert Doherty, Maithreyi Srikanth, Pedro Lowenstein, Maria Castro

2017, Clinical Cancer Research - Article

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