Engineering patient-specific cancer immunotherapies

L Scheetz, KS Park, Q Li, Pedro Lowenstein, Maria Castro, Anna Schwendeman, James Moon

2019, Nature Biomedical Engineering - Article

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

FJ Núñez, FM Mendez, P Kadiyala, . Alghamri, . Savelieff, MB Garcia-Fabiani, S Haase, Carl Koschmann, AA Calinescu, N Kamran, M Saxena, R Patel, S Carney, MZ Guo, M Edwards, Mats Ljungman, Tingting Qin, Maureen Sartor, R Tagett, Sriram Venneti, J Brosnan-Cashman, A Meeker, V Gorbunova, Lili Zhao, DM Kremer, L Zhang, Costas Lyssiotis, L Jones, CJ Herting, JL Ross, D Hambardzumyan, S Hervey-Jumper, ME Figueroa, Pedro Lowenstein, Maria Castro

2019, Science Translational Medicine - Article

Effect of caveolin-1 on Stat3-ptyr705 levels in breast and lung carcinoma cells

M Geletu, Z Taha, R Arulanandam, R Mohan, HH Assi, Maria Castro, IR Nabi, PT Gunning, L Raptis

2019, Biochemistry and Cell Biology - Article

Functional assay to assess T-cell inhibitory properties of myeloid derived suppressor cells (MDSCs) isolated from the tumor microenvironment of murine glioma models

. Alghamri, N Kamran, P Kadiyala, Pedro Lowenstein, Maria Castro

2019, Methods in Enzymology - Chapter

Isolation and characterization of immune cells from the tumor microenvironment of genetically engineered pediatric high-grade glioma models using the sleeping beauty transposon system

MB Garcia-Fabiani, A Comba, P Kadiyala, S Haase, FJ Núñez, D Altshuler, Pedro Lowenstein, Maria Castro

2019, Methods in Enzymology - Chapter

Functional characterization of tumor antigen-specific T-cells isolated from the tumor microenvironment of sleeping beauty induced murine glioma models

. Alghamri, FJ Núñez, N Kamran, S Carney, D Altshuler, Pedro Lowenstein, Maria Castro

2019, Methods in Enzymology - Chapter

A platform for artificial intelligence based identification of the extravasation potential of cancer cells into the brain metastatic niche

CR Oliver, MA Altemus, TM Westerhof, H Cheriyan, X Cheng, M Dziubinski, Z Wu, J Yates, A Morikawa, Jason Heth, Maria Castro, BM Leung, S Takayama, Sofia Merajver

2019, Lab on a Chip - Article

High-Density Lipoprotein-Mimicking Nanodiscs for Chemo-immunotherapy against Glioblastoma Multiforme

P Kadiyala, D Li, FM Nunez, D Altshuler, R Doherty, R Kuai, M Yu, N Kamran, M Edwards, JJ Moon, Pedro Lowenstein, Maria Castro, Anna Schwendeman

2019, ACS Nano - Article

Evaluation of biomarkers in glioma by immunohistochemistry on paraffin- embedded 3D glioma neurosphere cultures

FJ Núñez, FM Mendez, MB Garcia-Fabiani, J Pardo, M Edwards, Pedro Lowenstein, Maria Castro

2019, Journal of Visualized Experiments - Article

Immature myeloid cells in the tumor microenvironment: Implications for immunotherapy

N Kamran, M Chandran, Pedro Lowenstein, Maria Castro

2018, Clinical Immunology - Article

Evolutionary basis of a new gene- and immune-therapeutic approach for the treatment of malignant brain tumors: from mice to clinical trials for glioma patients

Pedro Lowenstein, Maria Castro

2018, Clinical Immunology - Article

Melanoma induced immunosuppression is mediated by hematopoietic dysregulation

N Kamran, Y Li, M Sierra, . Alghamri, P Kadiyala, Henry Appelman, M Edwards, Pedro Lowenstein, Maria Castro

2018, OncoImmunology - Article

Native chromatin immunoprecipitation using murine brain tumor neurospheres

FM Mendez, FJ Núñez, RI Zorrilla-Veloz, Pedro Lowenstein, Maria Castro

2018, Journal of Visualized Experiments - Article

Molecular ablation of tumor blood vessels inhibits therapeutic effects of radiation and bevacizumab

Vivekanand Yadav, D Altshuler, P Kadiyala, D Zamler, A Comba, Henry Appelman, P Dunn, Carl Koschmann, Maria Castro, PR Löwenstein, Pedro Lowenstein

2018, Neuro-Oncology - Article

Dual activation of Toll-like receptors 7 and 9 impairs the efficacy of antitumor vaccines in murine models of metastatic breast cancer

MA Moreno Ayala, MF Gottardo, . Gori, AJ Nicola Candia, C Caruso, A De Laurentiis, M Imsen, S Klein, E Bal de Kier Joffé, G Salamone, Maria Castro, A Seilicovich, M Candolfi

2017, Journal of Cancer Research and Clinical Oncology - Article

Single vs. combination immunotherapeutic strategies for glioma

M Chandran, M Candolfi, D Shah, Y Mineharu, Vivekanand Yadav, Carl Koschmann, AS Asad, Pedro Lowenstein, Maria Castro

2017, Expert Opinion on Biological Therapy - Article

Survival and proliferation of neural progenitor-derived glioblastomas under hypoxic stress is controlled by a CXCL12/CXCR4 Autocrine-Positive Feedback Mechanism

Anda-Alexandra Calinescu, Vivekanand Yadav, E Carballo, P Kadiyala, D Tran, DB Zamler, R Doherty, M Srikanth, Pedro Lowenstein, Maria Castro

2017, Clinical Cancer Research - Article

Mutated chromatin regulatory factors as tumor drivers in cancer

Carl Koschmann, FJ Nunez, F Mendez, JA Brosnan-Cashman, AK Meeker, Pedro Lowenstein, Maria Castro

2017, Cancer Research - Article

Immunosuppressive Myeloid Cells’ Blockade in the Glioma Microenvironment Enhances the Efficacy of Immune-Stimulatory Gene Therapy

N Kamran, P Kadiyala, M Saxena, M Candolfi, Y Li, MA Moreno-Ayala, N Raja, D Shah, Pedro Lowenstein, Maria Castro

2017, Molecular Therapy - Article

Matrix metalloproteinase activity in infections by an encephalitic virus, mouse adenovirus type 1

SL Ashley, CD Pretto, MT Stier, P Kadiyala, L Castro-Jorge, TH Hsu, R Doherty, KE Carnahan, Maria Castro, Pedro Lowenstein, Katherine Spindler

2017, Journal of Virology - Article

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